Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model

Population aging is a prominent global problem in today’s society. However, there are currently no good methods to treat or prevent aging, so anti-aging research has crucial implications. In this research, we screened bacteria from centenarians, and finally selected four probiotics (Lactobacillus fe...

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Autores principales:	Xin Fang, Mengyun Yue, Jing Wei, Yun Wang, Daojun Hong, Bo Wang, Xiaoting Zhou, Tingtao Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging SAMP8 mice TLR4/NFκB neuroinflammation probiotic combination Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/354d1d17fb4e416ba93845eecdfe4350
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spelling	oai:doaj.org-article:354d1d17fb4e416ba93845eecdfe43502021-12-02T07:10:40ZEvaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model1664-322410.3389/fimmu.2021.792746https://doaj.org/article/354d1d17fb4e416ba93845eecdfe43502021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.792746/fullhttps://doaj.org/toc/1664-3224Population aging is a prominent global problem in today’s society. However, there are currently no good methods to treat or prevent aging, so anti-aging research has crucial implications. In this research, we screened bacteria from centenarians, and finally selected four probiotics (Lactobacillus fermentum SX-0718, L. casei SX-1107, Bifidobacterium longum SX-1326, and B. animalis SX-0582) to form a probiotic combination. By using the senescence accelerated mouse prone 8 (SAMP8) model, the anti-aging effects of the probiotic combination were evaluated by using behavioural testing, neuroinflammation, intestinal inflammation, and intestinal microbiota. The results showed that probiotic combination improved the impaired spatial memory, motor dysfunction, and decreased exploratory behavior in aging mice. The probiotic combination inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NFκB)-induced neuroinflammation and up-regulated the expression of Sirt 1 to protect hippocampal neurons. At the same time, the probiotic combination regulated the intestinal microbiota, reduced the relative abundance of Alistipes and Prevotella in SAMP8 mice, inhibited TLR4/NFκB-induced intestinal inflammation, and increased the expression of intestinal permeability related proteins zonula occludens-1 (ZO-1) and Occuldin. The anti-aging effects of the probiotic combination may be through the regulating intestinal microbiota and inhibiting TLR4/NFκB-induced inflammation. This research provides the basis and technical support for the future production and application of the probiotic combination.Xin FangMengyun YueJing WeiYun WangDaojun HongBo WangXiaoting ZhouTingtao ChenTingtao ChenFrontiers Media S.A.articleagingSAMP8 miceTLR4/NFκBneuroinflammationprobiotic combinationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging SAMP8 mice TLR4/NFκB neuroinflammation probiotic combination Immunologic diseases. Allergy RC581-607
spellingShingle	aging SAMP8 mice TLR4/NFκB neuroinflammation probiotic combination Immunologic diseases. Allergy RC581-607 Xin Fang Mengyun Yue Jing Wei Yun Wang Daojun Hong Bo Wang Xiaoting Zhou Tingtao Chen Tingtao Chen Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
description	Population aging is a prominent global problem in today’s society. However, there are currently no good methods to treat or prevent aging, so anti-aging research has crucial implications. In this research, we screened bacteria from centenarians, and finally selected four probiotics (Lactobacillus fermentum SX-0718, L. casei SX-1107, Bifidobacterium longum SX-1326, and B. animalis SX-0582) to form a probiotic combination. By using the senescence accelerated mouse prone 8 (SAMP8) model, the anti-aging effects of the probiotic combination were evaluated by using behavioural testing, neuroinflammation, intestinal inflammation, and intestinal microbiota. The results showed that probiotic combination improved the impaired spatial memory, motor dysfunction, and decreased exploratory behavior in aging mice. The probiotic combination inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NFκB)-induced neuroinflammation and up-regulated the expression of Sirt 1 to protect hippocampal neurons. At the same time, the probiotic combination regulated the intestinal microbiota, reduced the relative abundance of Alistipes and Prevotella in SAMP8 mice, inhibited TLR4/NFκB-induced intestinal inflammation, and increased the expression of intestinal permeability related proteins zonula occludens-1 (ZO-1) and Occuldin. The anti-aging effects of the probiotic combination may be through the regulating intestinal microbiota and inhibiting TLR4/NFκB-induced inflammation. This research provides the basis and technical support for the future production and application of the probiotic combination.
format	article
author	Xin Fang Mengyun Yue Jing Wei Yun Wang Daojun Hong Bo Wang Xiaoting Zhou Tingtao Chen Tingtao Chen
author_facet	Xin Fang Mengyun Yue Jing Wei Yun Wang Daojun Hong Bo Wang Xiaoting Zhou Tingtao Chen Tingtao Chen
author_sort	Xin Fang
title	Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
title_short	Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
title_full	Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
title_fullStr	Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
title_full_unstemmed	Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
title_sort	evaluation of the anti-aging effects of a probiotic combination isolated from centenarians in a samp8 mouse model
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/354d1d17fb4e416ba93845eecdfe4350
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Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model

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