Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan

Abstract Background Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxidative effects of the juice of Vitis ficifolia var. ganebu (known as...

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Autores principales:	Sakae Arimoto-Kobayashi, Ryoko Hida, Nana Fujii, Ryosuke Mochioka
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Antimutagenesis Anti-inflammation Acute edema In vivo anti-lipid peroxidation Wild grape juice Ryukyu-ganebu Ecology QH540-549.5 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/355269fadfda4270a8c8e9ae450aa590
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spelling	oai:doaj.org-article:355269fadfda4270a8c8e9ae450aa5902021-11-14T12:16:30ZAntimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan10.1186/s41021-021-00225-y1880-7062https://doaj.org/article/355269fadfda4270a8c8e9ae450aa5902021-11-01T00:00:00Zhttps://doi.org/10.1186/s41021-021-00225-yhttps://doaj.org/toc/1880-7062Abstract Background Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxidative effects of the juice of Vitis ficifolia var. ganebu (known as Ryukyu-ganebu in Japan) harvested in Kuchinoshima island (hereafter, the juice is referred to as ganebu-K) in comparison with the juice of Vitis coignetiae (crimson glory vine, known as yamabudo in Japan; hereafter, the juice is referred to as yamabudo) which we found antimutagenic and anti-inflammatory effects. Results Ganebu-K inhibited the mutagenic activity of several carcinogens, MeIQx, IQ, Trp-P-2(NHOH), and MNNG, model compounds of tumor initiation. Using S. typhimurium YG7108, a strain lacking O 6-methylguanine DNA methyltransferases, ganebu-K showed no significant inhibition of the mutagenicity of MNNG. Thus, DNA repair of O6-methylguanine produced by MNNG might be an antimutagenic target of the components in ganebu-K. Topical application of ganebu-K to the dorsal sides of mice resulted in potent suppression of acute edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Ganebu-K, but not yamabudo, exhibited significant inhibition of the induction of prostaglandin E2 (PGE2) induced by TPA. Components contained in ganebu-K, but not in yamabudo, might be responsible for the inhibition of the induction of PGE2. Ganebu-K inhibited in vivo lipid peroxidation and decreased the level of glutamic oxaloacetic transaminase induced by CCL4 treatment. Conclusions These results suggest that the active components in ganebu-K juice are not the same as those in yamabudo, and the components in ganebu-K are attractive candidates as chemopreventive agents.Sakae Arimoto-KobayashiRyoko HidaNana FujiiRyosuke MochiokaBMCarticleAntimutagenesisAnti-inflammationAcute edemaIn vivo anti-lipid peroxidationWild grape juiceRyukyu-ganebuEcologyQH540-549.5GeneticsQH426-470ENGenes and Environment, Vol 43, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antimutagenesis Anti-inflammation Acute edema In vivo anti-lipid peroxidation Wild grape juice Ryukyu-ganebu Ecology QH540-549.5 Genetics QH426-470
spellingShingle	Antimutagenesis Anti-inflammation Acute edema In vivo anti-lipid peroxidation Wild grape juice Ryukyu-ganebu Ecology QH540-549.5 Genetics QH426-470 Sakae Arimoto-Kobayashi Ryoko Hida Nana Fujii Ryosuke Mochioka Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
description	Abstract Background Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxidative effects of the juice of Vitis ficifolia var. ganebu (known as Ryukyu-ganebu in Japan) harvested in Kuchinoshima island (hereafter, the juice is referred to as ganebu-K) in comparison with the juice of Vitis coignetiae (crimson glory vine, known as yamabudo in Japan; hereafter, the juice is referred to as yamabudo) which we found antimutagenic and anti-inflammatory effects. Results Ganebu-K inhibited the mutagenic activity of several carcinogens, MeIQx, IQ, Trp-P-2(NHOH), and MNNG, model compounds of tumor initiation. Using S. typhimurium YG7108, a strain lacking O 6-methylguanine DNA methyltransferases, ganebu-K showed no significant inhibition of the mutagenicity of MNNG. Thus, DNA repair of O6-methylguanine produced by MNNG might be an antimutagenic target of the components in ganebu-K. Topical application of ganebu-K to the dorsal sides of mice resulted in potent suppression of acute edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Ganebu-K, but not yamabudo, exhibited significant inhibition of the induction of prostaglandin E2 (PGE2) induced by TPA. Components contained in ganebu-K, but not in yamabudo, might be responsible for the inhibition of the induction of PGE2. Ganebu-K inhibited in vivo lipid peroxidation and decreased the level of glutamic oxaloacetic transaminase induced by CCL4 treatment. Conclusions These results suggest that the active components in ganebu-K juice are not the same as those in yamabudo, and the components in ganebu-K are attractive candidates as chemopreventive agents.
format	article
author	Sakae Arimoto-Kobayashi Ryoko Hida Nana Fujii Ryosuke Mochioka
author_facet	Sakae Arimoto-Kobayashi Ryoko Hida Nana Fujii Ryosuke Mochioka
author_sort	Sakae Arimoto-Kobayashi
title	Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
title_short	Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
title_full	Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
title_fullStr	Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
title_full_unstemmed	Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
title_sort	antimutagenic, anti-inflammatory, and antioxidative activities of the juice of vitis ficifolia var. ganebu, a woody vine in the grape family, known as ryukyu-ganebu in japan
publisher	BMC
publishDate	2021
url	https://doaj.org/article/355269fadfda4270a8c8e9ae450aa590
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Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan

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