Setting the stage: The initial immune response to blood-stage parasites

Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, no...

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Autores principales:	Allison N. Bucşan, Kim C. Williamson
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	(5–10): malaria plasmodium falciparum monocytes dendritic cells gamma-delta t cells nk cells Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/35536fd17e33415da81db3a4f5f19e34
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spelling	oai:doaj.org-article:35536fd17e33415da81db3a4f5f19e342021-11-17T14:21:57ZSetting the stage: The initial immune response to blood-stage parasites2150-55942150-560810.1080/21505594.2019.1708053https://doaj.org/article/35536fd17e33415da81db3a4f5f19e342020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2019.1708053https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which complicates vaccine development. Progress has been made in defining the innate signaling pathways activated by parasite components, including DNA, RNA, hemozoin, and phospholipids, which initiate the immune response and will be the focus of this review. The challenge that remains within the field is to understand the role of these early responses in the development of protective adaptive responses that clear iRBC and block merozoite invasion so that optimal vaccines and therapeutics may be produced.Allison N. BucşanKim C. WilliamsonTaylor & Francis Grouparticle(5–10): malariaplasmodium falciparummonocytesdendritic cellsgamma-delta t cellsnk cellsInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 88-103 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	(5–10): malaria plasmodium falciparum monocytes dendritic cells gamma-delta t cells nk cells Infectious and parasitic diseases RC109-216
spellingShingle	(5–10): malaria plasmodium falciparum monocytes dendritic cells gamma-delta t cells nk cells Infectious and parasitic diseases RC109-216 Allison N. Bucşan Kim C. Williamson Setting the stage: The initial immune response to blood-stage parasites
description	Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which complicates vaccine development. Progress has been made in defining the innate signaling pathways activated by parasite components, including DNA, RNA, hemozoin, and phospholipids, which initiate the immune response and will be the focus of this review. The challenge that remains within the field is to understand the role of these early responses in the development of protective adaptive responses that clear iRBC and block merozoite invasion so that optimal vaccines and therapeutics may be produced.
format	article
author	Allison N. Bucşan Kim C. Williamson
author_facet	Allison N. Bucşan Kim C. Williamson
author_sort	Allison N. Bucşan
title	Setting the stage: The initial immune response to blood-stage parasites
title_short	Setting the stage: The initial immune response to blood-stage parasites
title_full	Setting the stage: The initial immune response to blood-stage parasites
title_fullStr	Setting the stage: The initial immune response to blood-stage parasites
title_full_unstemmed	Setting the stage: The initial immune response to blood-stage parasites
title_sort	setting the stage: the initial immune response to blood-stage parasites
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/35536fd17e33415da81db3a4f5f19e34
work_keys_str_mv	AT allisonnbucsan settingthestagetheinitialimmuneresponsetobloodstageparasites AT kimcwilliamson settingthestagetheinitialimmuneresponsetobloodstageparasites
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Setting the stage: The initial immune response to blood-stage parasites

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