Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus

Akram Shmendi,1 Fraser Pirie,2 Datshana P Naidoo,3 Boikhutso Tlou,4 Wilfred Pilloy,5 Ayesha A Motala2 1Department of Medicine, 2Department of Diabetes and Endocrinology, 3Department of Cardiology, 4Department of Biostatistics, 5Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, So...

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Autores principales:	Shmendi A, Pirie F, Naidoo DP, Tlou B, Pilloy W, Motala AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3553e6d60b184b52b9a40af5c78078bc
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spelling	oai:doaj.org-article:3553e6d60b184b52b9a40af5c78078bc2021-12-02T08:25:18ZMyocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus1178-7007https://doaj.org/article/3553e6d60b184b52b9a40af5c78078bc2014-11-01T00:00:00Zhttp://www.dovepress.com/myocardial-perfusion-imaging-for-evaluation-of-suspected-ischemia-and--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Akram Shmendi,1 Fraser Pirie,2 Datshana P Naidoo,3 Boikhutso Tlou,4 Wilfred Pilloy,5 Ayesha A Motala2 1Department of Medicine, 2Department of Diabetes and Endocrinology, 3Department of Cardiology, 4Department of Biostatistics, 5Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, South Africa Background: The relationship between myocardial perfusion imaging (MPI) abnormalities, diabetes mellitus, and glucose control in South African populations is unknown. It was hypothesized that in subjects undergoing MPI for suspected coronary artery disease (CAD), those with diabetes would have more extensive perfusion defects and that diabetes control would influence MPI abnormalities. The aim of this study was to examine the relationship between the severity of CAD diagnosed with MPI in subjects with and without diabetes and to determine the relationship between diabetes control and extent of CAD.Methods: This study was a retrospective chart review of 340 subjects in whom MPI scans were performed over a 12-month period.Results: Subjects with diabetes had a higher prevalence of abnormal MPI, with more extensive ischemia, compared with subjects without diabetes (85.6% versus 68%; odds ratio 2.81, P<0.01). Glycated hemoglobin ≥7.0% was associated with a higher risk of abnormal MPI, with more extensive ischemia, compared with subjects having diabetes and glycated hemoglobin <7.0% (odds ratio 2.46, P=0.03) and those without diabetes (odds ratio 4.55, P=0.0001).Conclusion: Subjects with diabetes have more extensive myocardial ischemia when compared with subjects without diabetes. Furthermore, poorer diabetes control is associated with more abnormalities on MPI scanning. Keywords: myocardial perfusion imaging, diabetes mellitus, coronary artery disease, glycated hemoglobinShmendi APirie FNaidoo DPTlou BPilloy WMotala AADove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 545-552 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Shmendi A Pirie F Naidoo DP Tlou B Pilloy W Motala AA Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
description	Akram Shmendi,1 Fraser Pirie,2 Datshana P Naidoo,3 Boikhutso Tlou,4 Wilfred Pilloy,5 Ayesha A Motala2 1Department of Medicine, 2Department of Diabetes and Endocrinology, 3Department of Cardiology, 4Department of Biostatistics, 5Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, South Africa Background: The relationship between myocardial perfusion imaging (MPI) abnormalities, diabetes mellitus, and glucose control in South African populations is unknown. It was hypothesized that in subjects undergoing MPI for suspected coronary artery disease (CAD), those with diabetes would have more extensive perfusion defects and that diabetes control would influence MPI abnormalities. The aim of this study was to examine the relationship between the severity of CAD diagnosed with MPI in subjects with and without diabetes and to determine the relationship between diabetes control and extent of CAD.Methods: This study was a retrospective chart review of 340 subjects in whom MPI scans were performed over a 12-month period.Results: Subjects with diabetes had a higher prevalence of abnormal MPI, with more extensive ischemia, compared with subjects without diabetes (85.6% versus 68%; odds ratio 2.81, P<0.01). Glycated hemoglobin ≥7.0% was associated with a higher risk of abnormal MPI, with more extensive ischemia, compared with subjects having diabetes and glycated hemoglobin <7.0% (odds ratio 2.46, P=0.03) and those without diabetes (odds ratio 4.55, P=0.0001).Conclusion: Subjects with diabetes have more extensive myocardial ischemia when compared with subjects without diabetes. Furthermore, poorer diabetes control is associated with more abnormalities on MPI scanning. Keywords: myocardial perfusion imaging, diabetes mellitus, coronary artery disease, glycated hemoglobin
format	article
author	Shmendi A Pirie F Naidoo DP Tlou B Pilloy W Motala AA
author_facet	Shmendi A Pirie F Naidoo DP Tlou B Pilloy W Motala AA
author_sort	Shmendi A
title	Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
title_short	Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
title_full	Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
title_fullStr	Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
title_full_unstemmed	Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus
title_sort	myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in south african subjects with diabetes mellitus
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/3553e6d60b184b52b9a40af5c78078bc
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Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus

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