Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity

Intertumor heterogeneity is common in various cancers and has been widely accepted as the primary cause of the diversity and variation of the effect of the same treatment on patients with the same type of tumor. Percutaneous microwave coagulation therapy (PMCT) is a minimally invasive and effective...

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Autores principales:	Haoyue Guo, Bin Chen, Wei Li, Hao Wang, Sha Zhao, Peixin Chen, Minlin Jiang, Lishu Zhao, Kandi Xu, Hui Sun, Yayi He, Caicun Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/35584b1a38f54e5eb181594b5cf508d6
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spelling	oai:doaj.org-article:35584b1a38f54e5eb181594b5cf508d62021-11-29T00:56:49ZPercutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity2040-230910.1155/2021/7773163https://doaj.org/article/35584b1a38f54e5eb181594b5cf508d62021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7773163https://doaj.org/toc/2040-2309Intertumor heterogeneity is common in various cancers and has been widely accepted as the primary cause of the diversity and variation of the effect of the same treatment on patients with the same type of tumor. Percutaneous microwave coagulation therapy (PMCT) is a minimally invasive and effective approach for destroying tumors by microwave beam under image guidance, which has been applied in lung cancer. However, no previous study has investigated the capability of PMCT solving intertumor heterogeneity. Here, we performed a component analysis of four lung cancer patients’ tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) and treated all four cases with PMCT. One patient’s TME could be classified into a hot tumor, mainly proinflammatory cytokines, and T cell infiltration. The other three patients’ TMEs were cold tumors, where immunosuppressive cells occupied a large proportion, including tumor-associated macrophages and cancer cells. Despite a high level of heterogeneity among their tumor microenvironment compositions, disease type and stage, and basic physical conditions, all four patients presented a stable disease (SD) without any cancer cell detected in the TME of cancer tissues after PMCT. In conclusion, this report uniquely contributed to the knowledge of the PMCT adaptation to tumor heterogeneity. Therefore, PMCT is promising to demonstrate a stable and robust antitumor efficacy in unresectable lung cancers with various TMEs.Haoyue GuoBin ChenWei LiHao WangSha ZhaoPeixin ChenMinlin JiangLishu ZhaoKandi XuHui SunYayi HeCaicun ZhouHindawi LimitedarticleMedicine (General)R5-920Medical technologyR855-855.5ENJournal of Healthcare Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Medical technology R855-855.5
spellingShingle	Medicine (General) R5-920 Medical technology R855-855.5 Haoyue Guo Bin Chen Wei Li Hao Wang Sha Zhao Peixin Chen Minlin Jiang Lishu Zhao Kandi Xu Hui Sun Yayi He Caicun Zhou Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
description	Intertumor heterogeneity is common in various cancers and has been widely accepted as the primary cause of the diversity and variation of the effect of the same treatment on patients with the same type of tumor. Percutaneous microwave coagulation therapy (PMCT) is a minimally invasive and effective approach for destroying tumors by microwave beam under image guidance, which has been applied in lung cancer. However, no previous study has investigated the capability of PMCT solving intertumor heterogeneity. Here, we performed a component analysis of four lung cancer patients’ tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) and treated all four cases with PMCT. One patient’s TME could be classified into a hot tumor, mainly proinflammatory cytokines, and T cell infiltration. The other three patients’ TMEs were cold tumors, where immunosuppressive cells occupied a large proportion, including tumor-associated macrophages and cancer cells. Despite a high level of heterogeneity among their tumor microenvironment compositions, disease type and stage, and basic physical conditions, all four patients presented a stable disease (SD) without any cancer cell detected in the TME of cancer tissues after PMCT. In conclusion, this report uniquely contributed to the knowledge of the PMCT adaptation to tumor heterogeneity. Therefore, PMCT is promising to demonstrate a stable and robust antitumor efficacy in unresectable lung cancers with various TMEs.
format	article
author	Haoyue Guo Bin Chen Wei Li Hao Wang Sha Zhao Peixin Chen Minlin Jiang Lishu Zhao Kandi Xu Hui Sun Yayi He Caicun Zhou
author_facet	Haoyue Guo Bin Chen Wei Li Hao Wang Sha Zhao Peixin Chen Minlin Jiang Lishu Zhao Kandi Xu Hui Sun Yayi He Caicun Zhou
author_sort	Haoyue Guo
title	Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
title_short	Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
title_full	Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
title_fullStr	Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
title_full_unstemmed	Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity
title_sort	percutaneous microwave coagulation therapy: a promising therapeutic method for breaking the barrier of the intertumor heterogeneity
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/35584b1a38f54e5eb181594b5cf508d6
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Percutaneous Microwave Coagulation Therapy: A Promising Therapeutic Method for Breaking the Barrier of the Intertumor Heterogeneity

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