Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative

Abstract Economic costs of osteoarthritis (OA) are considerable. However, there are no clinical tools to predict the progression of OA or guide patients to a correct treatment for preventing OA. We tested the ability of our cartilage degeneration algorithm to predict the subject-specific development...

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Autores principales:	Mimmi K. Liukkonen, Mika E. Mononen, Olesya Klets, Jari P. Arokoski, Simo Saarakkala, Rami K. Korhonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35585abc05704d6d8e18bbb8f241071a
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spelling	oai:doaj.org-article:35585abc05704d6d8e18bbb8f241071a2021-12-02T16:07:57ZSimulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative10.1038/s41598-017-09013-72045-2322https://doaj.org/article/35585abc05704d6d8e18bbb8f241071a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09013-7https://doaj.org/toc/2045-2322Abstract Economic costs of osteoarthritis (OA) are considerable. However, there are no clinical tools to predict the progression of OA or guide patients to a correct treatment for preventing OA. We tested the ability of our cartilage degeneration algorithm to predict the subject-specific development of OA and separate groups with different OA levels. The algorithm was able to predict OA progression similarly with the experimental follow-up data and separate subjects with radiographical OA (Kellgren-Lawrence (KL) grade 2 and 3) from healthy subjects (KL0). Maximum degeneration and degenerated volumes within cartilage were significantly higher (p < 0.05) in OA compared to healthy subjects, KL3 group showing the highest degeneration values. Presented algorithm shows a great potential to predict subject-specific progression of knee OA and has a clinical potential by simulating the effect of interventions on the progression of OA, thus helping decision making in an attempt to delay or prevent further OA symptoms.Mimmi K. LiukkonenMika E. MononenOlesya KletsJari P. ArokoskiSimo SaarakkalaRami K. KorhonenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mimmi K. Liukkonen Mika E. Mononen Olesya Klets Jari P. Arokoski Simo Saarakkala Rami K. Korhonen Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
description	Abstract Economic costs of osteoarthritis (OA) are considerable. However, there are no clinical tools to predict the progression of OA or guide patients to a correct treatment for preventing OA. We tested the ability of our cartilage degeneration algorithm to predict the subject-specific development of OA and separate groups with different OA levels. The algorithm was able to predict OA progression similarly with the experimental follow-up data and separate subjects with radiographical OA (Kellgren-Lawrence (KL) grade 2 and 3) from healthy subjects (KL0). Maximum degeneration and degenerated volumes within cartilage were significantly higher (p < 0.05) in OA compared to healthy subjects, KL3 group showing the highest degeneration values. Presented algorithm shows a great potential to predict subject-specific progression of knee OA and has a clinical potential by simulating the effect of interventions on the progression of OA, thus helping decision making in an attempt to delay or prevent further OA symptoms.
format	article
author	Mimmi K. Liukkonen Mika E. Mononen Olesya Klets Jari P. Arokoski Simo Saarakkala Rami K. Korhonen
author_facet	Mimmi K. Liukkonen Mika E. Mononen Olesya Klets Jari P. Arokoski Simo Saarakkala Rami K. Korhonen
author_sort	Mimmi K. Liukkonen
title	Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
title_short	Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
title_full	Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
title_fullStr	Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
title_full_unstemmed	Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative
title_sort	simulation of subject-specific progression of knee osteoarthritis and comparison to experimental follow-up data: data from the osteoarthritis initiative
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/35585abc05704d6d8e18bbb8f241071a
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Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative

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