Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

In the proteasome, Rpn2 provides the docking site for substrate receptor Rpn13. Here the authors present the structure of human Rpn13 Pru domain bound to its binding site in Rpn2 and provide insights into the mode of action for Rpn13-targeting molecule RA190, which has anticancer properties.

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Autores principales:	Xiuxiu Lu, Urszula Nowicka, Vinidhra Sridharan, Fen Liu, Leah Randles, David Hymel, Marzena Dyba, Sergey G. Tarasov, Nadya I. Tarasova, Xue Zhi Zhao, Jun Hamazaki, Shigeo Murata, Terrence R. Burke, Jr., Kylie J. Walters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3558b297c27d4dde9ca8b170d554b63a
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spelling	oai:doaj.org-article:3558b297c27d4dde9ca8b170d554b63a2021-12-02T14:42:20ZStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets10.1038/ncomms155402041-1723https://doaj.org/article/3558b297c27d4dde9ca8b170d554b63a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15540https://doaj.org/toc/2041-1723In the proteasome, Rpn2 provides the docking site for substrate receptor Rpn13. Here the authors present the structure of human Rpn13 Pru domain bound to its binding site in Rpn2 and provide insights into the mode of action for Rpn13-targeting molecule RA190, which has anticancer properties.Xiuxiu LuUrszula NowickaVinidhra SridharanFen LiuLeah RandlesDavid HymelMarzena DybaSergey G. TarasovNadya I. TarasovaXue Zhi ZhaoJun HamazakiShigeo MurataTerrence R. Burke, Jr.Kylie J. WaltersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiuxiu Lu Urszula Nowicka Vinidhra Sridharan Fen Liu Leah Randles David Hymel Marzena Dyba Sergey G. Tarasov Nadya I. Tarasova Xue Zhi Zhao Jun Hamazaki Shigeo Murata Terrence R. Burke, Jr. Kylie J. Walters Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
description	In the proteasome, Rpn2 provides the docking site for substrate receptor Rpn13. Here the authors present the structure of human Rpn13 Pru domain bound to its binding site in Rpn2 and provide insights into the mode of action for Rpn13-targeting molecule RA190, which has anticancer properties.
format	article
author	Xiuxiu Lu Urszula Nowicka Vinidhra Sridharan Fen Liu Leah Randles David Hymel Marzena Dyba Sergey G. Tarasov Nadya I. Tarasova Xue Zhi Zhao Jun Hamazaki Shigeo Murata Terrence R. Burke, Jr. Kylie J. Walters
author_facet	Xiuxiu Lu Urszula Nowicka Vinidhra Sridharan Fen Liu Leah Randles David Hymel Marzena Dyba Sergey G. Tarasov Nadya I. Tarasova Xue Zhi Zhao Jun Hamazaki Shigeo Murata Terrence R. Burke, Jr. Kylie J. Walters
author_sort	Xiuxiu Lu
title	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
title_short	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
title_full	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
title_fullStr	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
title_full_unstemmed	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
title_sort	structure of the rpn13-rpn2 complex provides insights for rpn13 and uch37 as anticancer targets
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3558b297c27d4dde9ca8b170d554b63a
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Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

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