BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA

Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the n...

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Autores principales:	K. K. Kulmukanova, A. U. Baiduissenova, E. A. Akhmediyarova, A. A. Yktiyarov, G. A. Bekniyazova, N. B. Rakhmetova, G. K. Smaylova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	immunological reactivity opiomania psychiatry and narcology organism reactivity opiate addiction Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/355a51eeb4944470a6abe9974ac17464
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spelling	oai:doaj.org-article:355a51eeb4944470a6abe9974ac174642021-11-18T08:03:51ZBODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA1563-06252313-741X10.15789/1563-0625-BIR-2289https://doaj.org/article/355a51eeb4944470a6abe9974ac174642021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2289https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDue to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the disease ranged from 0.5-19 years. Of these, the disease duration is up to 3 years – 28 patients (group I), and over 3 years – 52 patients (group II). The number of subjects in the control group was n = 50. Authors carried out the assessment of the mental, narcological, somatic, and neurological status. In addition, they have studied the general clinical, biochemical and immunological parameters As a result of this study, it was found, that patients of group I had more pronounced T-lymphocytopenia. A persistent increase in the value of serum IgM was revealed both in the dynamics of abstinence and depending on the duration of the disease, which may indicate a strain on the humoral link of immunity in opium addiction. In addition, as the duration of chronic narcotization increases, there is a tendency to increase the relative number of B-lymphocytes. Thus, at the patients with opium addiction in a state of abstinence develop T-lymphocytopenia. Moreover, with an increase in the duration of the disease, an increase in the level of IgM by 2-2.6 times. The revealed changes in the immunological reactivity of the organism suggest the need to include immunocorrective therapy in the complex of therapeutic measures for opium addiction.K. K. KulmukanovaA. U. BaiduissenovaE. A. AkhmediyarovaA. A. YktiyarovG. A. BekniyazovaN. B. RakhmetovaG. K. SmaylovaSPb RAACIarticleimmunological reactivityopiomaniapsychiatry and narcologyorganism reactivityopiate addictionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 781-784 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunological reactivity opiomania psychiatry and narcology organism reactivity opiate addiction Immunologic diseases. Allergy RC581-607
spellingShingle	immunological reactivity opiomania psychiatry and narcology organism reactivity opiate addiction Immunologic diseases. Allergy RC581-607 K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
description	Due to the general trend of changes in reactivity in many exogenous and endogenous diseases, more and more attention is currently being paid to changes in immunological reactivity in drug addiction. The expediency of assessing the state of immune mechanisms in opioid addiction is determined by the need to predict their course and outcome. The aim of the study was to study the immunological reactivity of the body in patients with opium addiction in a stage of abstinence. For this purpose, clinical and immunological studies were conducted in 80 patients who use opioid drugs. The duration of the disease ranged from 0.5-19 years. Of these, the disease duration is up to 3 years – 28 patients (group I), and over 3 years – 52 patients (group II). The number of subjects in the control group was n = 50. Authors carried out the assessment of the mental, narcological, somatic, and neurological status. In addition, they have studied the general clinical, biochemical and immunological parameters As a result of this study, it was found, that patients of group I had more pronounced T-lymphocytopenia. A persistent increase in the value of serum IgM was revealed both in the dynamics of abstinence and depending on the duration of the disease, which may indicate a strain on the humoral link of immunity in opium addiction. In addition, as the duration of chronic narcotization increases, there is a tendency to increase the relative number of B-lymphocytes. Thus, at the patients with opium addiction in a state of abstinence develop T-lymphocytopenia. Moreover, with an increase in the duration of the disease, an increase in the level of IgM by 2-2.6 times. The revealed changes in the immunological reactivity of the organism suggest the need to include immunocorrective therapy in the complex of therapeutic measures for opium addiction.
format	article
author	K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova
author_facet	K. K. Kulmukanova A. U. Baiduissenova E. A. Akhmediyarova A. A. Yktiyarov G. A. Bekniyazova N. B. Rakhmetova G. K. Smaylova
author_sort	K. K. Kulmukanova
title	BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
title_short	BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
title_full	BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
title_fullStr	BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
title_full_unstemmed	BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA
title_sort	body immunological reactivity in opiomania
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/355a51eeb4944470a6abe9974ac17464
work_keys_str_mv	AT kkkulmukanova bodyimmunologicalreactivityinopiomania AT aubaiduissenova bodyimmunologicalreactivityinopiomania AT eaakhmediyarova bodyimmunologicalreactivityinopiomania AT aayktiyarov bodyimmunologicalreactivityinopiomania AT gabekniyazova bodyimmunologicalreactivityinopiomania AT nbrakhmetova bodyimmunologicalreactivityinopiomania AT gksmaylova bodyimmunologicalreactivityinopiomania
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BODY IMMUNOLOGICAL REACTIVITY IN OPIOMANIA

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