Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to <i>para</i>-Quinone Methides

Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to <i>para</i>-Quinone Methides

The isothiourea-catalyzed enantioselective 1,6-conjugate addition of <i>para</i>-nitrophenyl esters to 2,6-disubstituted <i>para</i>-quinone methides is reported. <i>para</i>-Nitrophenoxide, generated in situ from initial <i>N</i>-acylation of the isot...

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Autores principales: Jude N. Arokianathar, Will C. Hartley, Calum McLaughlin, Mark D. Greenhalgh, Darren Stead, Sean Ng, Alexandra M. Z. Slawin, Andrew D. Smith
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
isothiourea
ammonium enolate
aryloxide
quinone methide
ester functionalization
1,6-conjugate addition
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/355f0306f6ad4c5f949bcd0c0470370b
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https://doaj.org/article/355f0306f6ad4c5f949bcd0c0470370b

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