Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

Osteochondroprogenitors are essential cells for skeletal development and homeostasis. Here the authors show that the desumoylase SENP6 suppresses p53 activity by desumoylating and stabilising TRIM28, and that SENP6 ablation leads to skeletal abnormalities, senescence in osteochondroprogenitors and c...

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Autores principales:	Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3565532495544c8b84b47ed37cbda2a1
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spelling	oai:doaj.org-article:3565532495544c8b84b47ed37cbda2a12021-12-02T16:56:37ZDesumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway10.1038/s41467-017-02413-32041-1723https://doaj.org/article/3565532495544c8b84b47ed37cbda2a12018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02413-3https://doaj.org/toc/2041-1723Osteochondroprogenitors are essential cells for skeletal development and homeostasis. Here the authors show that the desumoylase SENP6 suppresses p53 activity by desumoylating and stabilising TRIM28, and that SENP6 ablation leads to skeletal abnormalities, senescence in osteochondroprogenitors and chondrocytes, and premature ageing.Jianshuang LiDi LuHong DouHuadie LiuKevin WeaverWenjun WangJiada LiEdward T.H. YehBart O. WilliamsLing ZhengTao YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianshuang Li Di Lu Hong Dou Huadie Liu Kevin Weaver Wenjun Wang Jiada Li Edward T.H. Yeh Bart O. Williams Ling Zheng Tao Yang Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
description	Osteochondroprogenitors are essential cells for skeletal development and homeostasis. Here the authors show that the desumoylase SENP6 suppresses p53 activity by desumoylating and stabilising TRIM28, and that SENP6 ablation leads to skeletal abnormalities, senescence in osteochondroprogenitors and chondrocytes, and premature ageing.
format	article
author	Jianshuang Li Di Lu Hong Dou Huadie Liu Kevin Weaver Wenjun Wang Jiada Li Edward T.H. Yeh Bart O. Williams Ling Zheng Tao Yang
author_facet	Jianshuang Li Di Lu Hong Dou Huadie Liu Kevin Weaver Wenjun Wang Jiada Li Edward T.H. Yeh Bart O. Williams Ling Zheng Tao Yang
author_sort	Jianshuang Li
title	Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
title_short	Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
title_full	Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
title_fullStr	Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
title_full_unstemmed	Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
title_sort	desumoylase senp6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3565532495544c8b84b47ed37cbda2a1
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Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

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