Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

Osteochondroprogenitors are essential cells for skeletal development and homeostasis. Here the authors show that the desumoylase SENP6 suppresses p53 activity by desumoylating and stabilising TRIM28, and that SENP6 ablation leads to skeletal abnormalities, senescence in osteochondroprogenitors and c...

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Autores principales: Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/3565532495544c8b84b47ed37cbda2a1
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