Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives
Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:35666437d9934a83955e1849047aa3de2021-11-19T05:59:56ZImmunomodulation in the Treatment of Periodontitis: Progress and Perspectives1664-322410.3389/fimmu.2021.781378https://doaj.org/article/35666437d9934a83955e1849047aa3de2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.781378/fullhttps://doaj.org/toc/1664-3224Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis.Bo YangBo YangBo YangXuefei PangXuefei PangXuefei PangZhipeng LiZhipeng LiZhipeng LiZhuofan ChenZhuofan ChenZhuofan ChenYan WangYan WangYan WangFrontiers Media S.A.articleperiodontitisimmune microenvironment (IME)immunomodulationdrug therapymicrobial therapystem cell therapyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
periodontitis immune microenvironment (IME) immunomodulation drug therapy microbial therapy stem cell therapy Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
periodontitis immune microenvironment (IME) immunomodulation drug therapy microbial therapy stem cell therapy Immunologic diseases. Allergy RC581-607 Bo Yang Bo Yang Bo Yang Xuefei Pang Xuefei Pang Xuefei Pang Zhipeng Li Zhipeng Li Zhipeng Li Zhuofan Chen Zhuofan Chen Zhuofan Chen Yan Wang Yan Wang Yan Wang Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| description |
Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis. |
| format |
article |
| author |
Bo Yang Bo Yang Bo Yang Xuefei Pang Xuefei Pang Xuefei Pang Zhipeng Li Zhipeng Li Zhipeng Li Zhuofan Chen Zhuofan Chen Zhuofan Chen Yan Wang Yan Wang Yan Wang |
| author_facet |
Bo Yang Bo Yang Bo Yang Xuefei Pang Xuefei Pang Xuefei Pang Zhipeng Li Zhipeng Li Zhipeng Li Zhuofan Chen Zhuofan Chen Zhuofan Chen Yan Wang Yan Wang Yan Wang |
| author_sort |
Bo Yang |
| title |
Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| title_short |
Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| title_full |
Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| title_fullStr |
Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| title_full_unstemmed |
Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives |
| title_sort |
immunomodulation in the treatment of periodontitis: progress and perspectives |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/35666437d9934a83955e1849047aa3de |
| work_keys_str_mv |
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