Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?

Alessandro de Oliveira Silva,1,2 Ramires Alsamir Tibana,1 Margo Gomes Oliveira Karnikowski,3 Silvana Schwerz Funghetto,3 Jonato Prestes1 1Graduation Program in Physical Education and Health, Catholic University of Brasilia, 2Physical Education Department, Universitary Center of Brasilia, 3Ceilandia...

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Autores principales:	Oliveira Silva A, Tibana RA, Karnikowski MGO, Funghetto SS, Prestes J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	metabolic syndrome inflammation aging. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/356b4dc5b1f54a0980938cb1cbe103e3
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spelling	oai:doaj.org-article:356b4dc5b1f54a0980938cb1cbe103e32021-12-02T02:20:25ZInflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?1178-1998https://doaj.org/article/356b4dc5b1f54a0980938cb1cbe103e32013-03-01T00:00:00Zhttps://www.dovepress.com/inflammatory-status-in-older-women-with-and-without-metabolic-syndrome-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alessandro de Oliveira Silva,1,2 Ramires Alsamir Tibana,1 Margo Gomes Oliveira Karnikowski,3 Silvana Schwerz Funghetto,3 Jonato Prestes1 1Graduation Program in Physical Education and Health, Catholic University of Brasilia, 2Physical Education Department, Universitary Center of Brasilia, 3Ceilandia Faculty, University of Brasilia, Brasilia, Brazil Purpose: To compare the inflammatory status in older women with and without metabolic syndrome (MetS) and to correlate inflammatory parameters, anthropometric measures, metabolic profile, and blood pressure with MetS Z-score. Methods: This cohort transversal study included 129 older women assigned into two groups: with MetS (n = 48; 66.4 ± 4.4 years; 68.1 ± 8.3 kg; 1.51 ± 0.06 m; 29.8 ± 3.9 kg/m2) and without MetS (n = 81; 68.0 ± 5.8 years; 61.0 ± 9.4 kg; 1.53 ± 0.06 m; 26.0 ± 3.9 kg/m2). Body composition was evaluated by dual-energy X-ray absorptiometry (General Electric-GE model 8548 BX1L, year 2005, Lunar DPX type, software Encore 2005; Rommelsdorf, Germany) and cytokines by enzyme-linked immunosorbent assay. Results: There was no difference between the groups regarding age, height, fat mass, glycosylated hemoglobin, total cholesterol, and low-density lipoprotein cholesterol. However, older women with MetS presented higher body mass, body mass index, waist and hip circumference, waist–hip and waist–height ratio, systolic, diastolic, and mean blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, MetS Z-score, tumor necrosis factor-α, interferon-γ, and lower lean body mass values compared to women without MetS. Moreover, there were correlations between MetS Z-score and body mass (r = 0.20), waist circumference (r = 0.26), waist–hip (r = 0.32) and waist–height ratio (r = 0.24), blood glucose (r = 0.24), insulin (r = 0.24), homeostasis model assessment of insulin resistance (r = 0.32), triglycerides (r = 0.39), tumor necrosis factor-α (r = 0.28), interferon-γ (r = 0.22), and inverse correlation with high-density lipoprotein cholesterol (r = −0.32). MetS Z-score was positively associated with systolic (r = 0.92), diastolic (r = 0.94), and mean blood pressure (r = 0.98). Conclusion: Older women with MetS have higher cytokine levels, anthropometric measures, metabolic profile, and blood pressure. Inflammatory cytokines may help to improve the understanding of the progression status of MetS in older persons. Keywords: metabolic syndrome, cytokines, agingOliveira Silva ATibana RAKarnikowski MGOFunghetto SSPrestes JDove Medical Pressarticlemetabolic syndromeinflammationaging.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 361-367 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome inflammation aging. Geriatrics RC952-954.6
spellingShingle	metabolic syndrome inflammation aging. Geriatrics RC952-954.6 Oliveira Silva A Tibana RA Karnikowski MGO Funghetto SS Prestes J Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
description	Alessandro de Oliveira Silva,1,2 Ramires Alsamir Tibana,1 Margo Gomes Oliveira Karnikowski,3 Silvana Schwerz Funghetto,3 Jonato Prestes1 1Graduation Program in Physical Education and Health, Catholic University of Brasilia, 2Physical Education Department, Universitary Center of Brasilia, 3Ceilandia Faculty, University of Brasilia, Brasilia, Brazil Purpose: To compare the inflammatory status in older women with and without metabolic syndrome (MetS) and to correlate inflammatory parameters, anthropometric measures, metabolic profile, and blood pressure with MetS Z-score. Methods: This cohort transversal study included 129 older women assigned into two groups: with MetS (n = 48; 66.4 ± 4.4 years; 68.1 ± 8.3 kg; 1.51 ± 0.06 m; 29.8 ± 3.9 kg/m2) and without MetS (n = 81; 68.0 ± 5.8 years; 61.0 ± 9.4 kg; 1.53 ± 0.06 m; 26.0 ± 3.9 kg/m2). Body composition was evaluated by dual-energy X-ray absorptiometry (General Electric-GE model 8548 BX1L, year 2005, Lunar DPX type, software Encore 2005; Rommelsdorf, Germany) and cytokines by enzyme-linked immunosorbent assay. Results: There was no difference between the groups regarding age, height, fat mass, glycosylated hemoglobin, total cholesterol, and low-density lipoprotein cholesterol. However, older women with MetS presented higher body mass, body mass index, waist and hip circumference, waist–hip and waist–height ratio, systolic, diastolic, and mean blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, MetS Z-score, tumor necrosis factor-α, interferon-γ, and lower lean body mass values compared to women without MetS. Moreover, there were correlations between MetS Z-score and body mass (r = 0.20), waist circumference (r = 0.26), waist–hip (r = 0.32) and waist–height ratio (r = 0.24), blood glucose (r = 0.24), insulin (r = 0.24), homeostasis model assessment of insulin resistance (r = 0.32), triglycerides (r = 0.39), tumor necrosis factor-α (r = 0.28), interferon-γ (r = 0.22), and inverse correlation with high-density lipoprotein cholesterol (r = −0.32). MetS Z-score was positively associated with systolic (r = 0.92), diastolic (r = 0.94), and mean blood pressure (r = 0.98). Conclusion: Older women with MetS have higher cytokine levels, anthropometric measures, metabolic profile, and blood pressure. Inflammatory cytokines may help to improve the understanding of the progression status of MetS in older persons. Keywords: metabolic syndrome, cytokines, aging
format	article
author	Oliveira Silva A Tibana RA Karnikowski MGO Funghetto SS Prestes J
author_facet	Oliveira Silva A Tibana RA Karnikowski MGO Funghetto SS Prestes J
author_sort	Oliveira Silva A
title	Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
title_short	Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
title_full	Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
title_fullStr	Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
title_full_unstemmed	Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
title_sort	inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/356b4dc5b1f54a0980938cb1cbe103e3
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Inflammatory status in older women with and without metabolic syndrome: is there a correlation with risk factors?

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