Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome

Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome

Andrei Vitel,1,* Ioan Sporea,2 Ruxandra Mare,2 Christian Banciu,2 Diana-Aurora Bordejevic,1,* Tudor Parvanescu,1 Ioana Mihaela Citu,1 Mirela Cleopatra Tomescu1 1Cardiology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Gastroenterology Depart...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Vitel A, Sporea I, Mare R, Banciu C, Bordejevic DA, Parvanescu T, Citu IM, Tomescu MC
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
metabolic syndrome
left ventricular function
strain and strain‑rate imaging
liver steatosis and fibrosis
liver elastography
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/356e00b13523435daae5523b4524b65b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:356e00b13523435daae5523b4524b65b
record_format dspace
spelling oai:doaj.org-article:356e00b13523435daae5523b4524b65b2021-12-02T11:21:00ZAssociation Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome1178-7007https://doaj.org/article/356e00b13523435daae5523b4524b65b2020-10-01T00:00:00Zhttps://www.dovepress.com/association-between-subclinical-left-ventricular-myocardial-systolic-d-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Andrei Vitel,1,* Ioan Sporea,2 Ruxandra Mare,2 Christian Banciu,2 Diana-Aurora Bordejevic,1,* Tudor Parvanescu,1 Ioana Mihaela Citu,1 Mirela Cleopatra Tomescu1 1Cardiology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Gastroenterology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania*These authors contributed equally to this workCorrespondence: Ioana Mihaela CituCardiology Department, “Victor Babes” University of Medicine and Pharmacy, 2 nd Eftimie Murgu Square, Timisoara, RomaniaTel +40 724353666Fax +40 256220636Email ioanamihaela2010@gmail.comPurpose: The components of metabolic syndrome (MS) are risk factors for developing both cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Strain (SI) and strain‑rate imaging (SRI) are able to recognize early changes in cardiac function. Vibration-controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) detect and quantify liver fibrosis and steatosis. We aimed to assess whether there is any correlation between liver fibrosis and steatosis and left ventricular (LV) dysfunction in MS patients.Patients and Methods: A total of 150 adults with MS were registered in the study. They were compared with a control group of 150 age- and sex-matched adults without MS. After the classic echocardiographic assessment of LV function, two-dimensional speckle echocardiography (2D-STE) was used to evaluate LV peak systolic strain (S) and peak systolic strain rate (SR), while liver steatosis and fibrosis were evaluated by VCTE and CAP.Results: LV diastolic dysfunction was significantly more frequent among the patients with MS. We found significant differences between the two groups regarding the presence of subtle LV systolic dysfunction, detected by reduced values of S and SR. The risk for LV diastolic dysfunction was 3.6 times higher in MS with severe steatosis and 8 times higher in patients with severe fibrosis, P< 0.0001. The risk for LV systolic dysfunction was double in MS with severe steatosis and 1.7 times higher in MS with severe fibrosis, P< 0.0001.Conclusion: In MS patients with normal LV ejection fraction, conventional echocardiography parameters identified diastolic LV dysfunction, while SI and SRI identified subtle impairment of systolic LV dysfunction. The presence of hepatic steatosis and fibrosis increases significantly the risk for cardiac dysfunction in MS patients (P< 0.0001).Keywords: metabolic syndrome, left ventricular function, strain and strain‑rate imaging, liver steatosis and fibrosis, liver elastographyVitel ASporea IMare RBanciu CBordejevic DAParvanescu TCitu IMTomescu MCDove Medical Pressarticlemetabolic syndromeleft ventricular functionstrain and strain‑rate imagingliver steatosis and fibrosisliver elastographySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3749-3759 (2020)
institution DOAJ
collection DOAJ
language EN
topic metabolic syndrome
left ventricular function
strain and strain‑rate imaging
liver steatosis and fibrosis
liver elastography
Specialties of internal medicine
RC581-951
spellingShingle metabolic syndrome
left ventricular function
strain and strain‑rate imaging
liver steatosis and fibrosis
liver elastography
Specialties of internal medicine
RC581-951
Vitel A
Sporea I
Mare R
Banciu C
Bordejevic DA
Parvanescu T
Citu IM
Tomescu MC
Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
description Andrei Vitel,1,* Ioan Sporea,2 Ruxandra Mare,2 Christian Banciu,2 Diana-Aurora Bordejevic,1,* Tudor Parvanescu,1 Ioana Mihaela Citu,1 Mirela Cleopatra Tomescu1 1Cardiology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Gastroenterology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania*These authors contributed equally to this workCorrespondence: Ioana Mihaela CituCardiology Department, “Victor Babes” University of Medicine and Pharmacy, 2 nd Eftimie Murgu Square, Timisoara, RomaniaTel +40 724353666Fax +40 256220636Email ioanamihaela2010@gmail.comPurpose: The components of metabolic syndrome (MS) are risk factors for developing both cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Strain (SI) and strain‑rate imaging (SRI) are able to recognize early changes in cardiac function. Vibration-controlled transient elastography (VCTE) and controlled attenuation parameter (CAP) detect and quantify liver fibrosis and steatosis. We aimed to assess whether there is any correlation between liver fibrosis and steatosis and left ventricular (LV) dysfunction in MS patients.Patients and Methods: A total of 150 adults with MS were registered in the study. They were compared with a control group of 150 age- and sex-matched adults without MS. After the classic echocardiographic assessment of LV function, two-dimensional speckle echocardiography (2D-STE) was used to evaluate LV peak systolic strain (S) and peak systolic strain rate (SR), while liver steatosis and fibrosis were evaluated by VCTE and CAP.Results: LV diastolic dysfunction was significantly more frequent among the patients with MS. We found significant differences between the two groups regarding the presence of subtle LV systolic dysfunction, detected by reduced values of S and SR. The risk for LV diastolic dysfunction was 3.6 times higher in MS with severe steatosis and 8 times higher in patients with severe fibrosis, P< 0.0001. The risk for LV systolic dysfunction was double in MS with severe steatosis and 1.7 times higher in MS with severe fibrosis, P< 0.0001.Conclusion: In MS patients with normal LV ejection fraction, conventional echocardiography parameters identified diastolic LV dysfunction, while SI and SRI identified subtle impairment of systolic LV dysfunction. The presence of hepatic steatosis and fibrosis increases significantly the risk for cardiac dysfunction in MS patients (P< 0.0001).Keywords: metabolic syndrome, left ventricular function, strain and strain‑rate imaging, liver steatosis and fibrosis, liver elastography
format article
author Vitel A
Sporea I
Mare R
Banciu C
Bordejevic DA
Parvanescu T
Citu IM
Tomescu MC
author_facet Vitel A
Sporea I
Mare R
Banciu C
Bordejevic DA
Parvanescu T
Citu IM
Tomescu MC
author_sort Vitel A
title Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
title_short Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
title_full Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
title_fullStr Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
title_full_unstemmed Association Between Subclinical Left Ventricular Myocardial Systolic Dysfunction Detected by Strain and Strain‑Rate Imaging and Liver Steatosis and Fibrosis Detected by Elastography and Controlled Attenuation Parameter in Patients with Metabolic Syndrome
title_sort association between subclinical left ventricular myocardial systolic dysfunction detected by strain and strain‑rate imaging and liver steatosis and fibrosis detected by elastography and controlled attenuation parameter in patients with metabolic syndrome
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/356e00b13523435daae5523b4524b65b
work_keys_str_mv AT vitela associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT sporeai associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT marer associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT banciuc associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT bordejevicda associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT parvanescut associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT cituim associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
AT tomescumc associationbetweensubclinicalleftventricularmyocardialsystolicdysfunctiondetectedbystrainandstrainrateimagingandliversteatosisandfibrosisdetectedbyelastographyandcontrolledattenuationparameterinpatientswithmetabolicsyndrome
_version_ 1718395987176718336

Ejemplares similares