The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases

Abstract The literature discussing the long-term outcome after resection of upper cervical spinal cord tumors is limited. The purpose of this study was to review the progression-free survival (PFS), overall survival (OS), and long-term outcomes in a consecutive series of 51 patients with upper cervi...

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Autores principales:	Xin Wang, Jun Gao, Tianyu Wang, Zhimin Li, Yongning Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Cervical Spinal Cord Tumors Gross Total Resection (GTR) Intraspinal Tumors JOA Score Subtotal Resection (STR) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/356f80b5a4974e51b8358bb8b032e284
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spelling	oai:doaj.org-article:356f80b5a4974e51b8358bb8b032e2842021-12-02T15:07:52ZThe Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases10.1038/s41598-018-33263-82045-2322https://doaj.org/article/356f80b5a4974e51b8358bb8b032e2842018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33263-8https://doaj.org/toc/2045-2322Abstract The literature discussing the long-term outcome after resection of upper cervical spinal cord tumors is limited. The purpose of this study was to review the progression-free survival (PFS), overall survival (OS), and long-term outcomes in a consecutive series of 51 patients with upper cervical spinal cord tumors who underwent surgery at our institution between 2005 and 2010. Patient outcome were evaluated using the Japanese Orthopaedic Association score (JOA) and the McCormick functional schema. Follow-up data was collected completely and the median follow-up time was 6.1 years. Gross total resection (GTR) was performed in 27 patients (52.94%) and subtotal resection (STR) in 24 patients (47.06%). Progression-free survival and overall survival at 5 years was 88.23% and 92.16%, respectively. Good prognosis was defined as 74.51% based on JOA scoring. The univariate analysis showed that patients over 60y, tumors located higher than C2, tumor size greater than 4 cm as well as malignant tumors and subtotal resection were factors indicating a poor prognosis. However, the multivariate regression analyses showed only the level of tumor and tumor size were independent risk factors for a poor prognosis. The gold standard treatment for intraspinal tumors is gross total resection and follow-up should be focused on patients with a high risk of poor prognosis.Xin WangJun GaoTianyu WangZhimin LiYongning LiNature PortfolioarticleCervical Spinal Cord TumorsGross Total Resection (GTR)Intraspinal TumorsJOA ScoreSubtotal Resection (STR)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical Spinal Cord Tumors Gross Total Resection (GTR) Intraspinal Tumors JOA Score Subtotal Resection (STR) Medicine R Science Q
spellingShingle	Cervical Spinal Cord Tumors Gross Total Resection (GTR) Intraspinal Tumors JOA Score Subtotal Resection (STR) Medicine R Science Q Xin Wang Jun Gao Tianyu Wang Zhimin Li Yongning Li The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
description	Abstract The literature discussing the long-term outcome after resection of upper cervical spinal cord tumors is limited. The purpose of this study was to review the progression-free survival (PFS), overall survival (OS), and long-term outcomes in a consecutive series of 51 patients with upper cervical spinal cord tumors who underwent surgery at our institution between 2005 and 2010. Patient outcome were evaluated using the Japanese Orthopaedic Association score (JOA) and the McCormick functional schema. Follow-up data was collected completely and the median follow-up time was 6.1 years. Gross total resection (GTR) was performed in 27 patients (52.94%) and subtotal resection (STR) in 24 patients (47.06%). Progression-free survival and overall survival at 5 years was 88.23% and 92.16%, respectively. Good prognosis was defined as 74.51% based on JOA scoring. The univariate analysis showed that patients over 60y, tumors located higher than C2, tumor size greater than 4 cm as well as malignant tumors and subtotal resection were factors indicating a poor prognosis. However, the multivariate regression analyses showed only the level of tumor and tumor size were independent risk factors for a poor prognosis. The gold standard treatment for intraspinal tumors is gross total resection and follow-up should be focused on patients with a high risk of poor prognosis.
format	article
author	Xin Wang Jun Gao Tianyu Wang Zhimin Li Yongning Li
author_facet	Xin Wang Jun Gao Tianyu Wang Zhimin Li Yongning Li
author_sort	Xin Wang
title	The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
title_short	The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
title_full	The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
title_fullStr	The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
title_full_unstemmed	The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases
title_sort	long-term outcome after resection of upper cervical spinal cord tumors: report of 51 consecutive cases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/356f80b5a4974e51b8358bb8b032e284
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The Long-term Outcome After Resection of Upper Cervical Spinal Cord Tumors: Report of 51 Consecutive Cases

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