Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation

Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitoring during cardiopulmonary resuscitation (CPR), and...

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Autores principales:	Tiffany S. Ko, Constantine D. Mavroudis, Ryan W. Morgan, Wesley B. Baker, Alexandra M. Marquez, Timothy W. Boorady, Mahima Devarajan, Yuxi Lin, Anna L. Roberts, William P. Landis, Kobina Mensah-Brown, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Arjun G. Yodh, Daniel J. Licht, Wensheng Guo, Todd J. Kilbaugh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/357b300a7e434438a8ef0a890b5f4cb3
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spelling	oai:doaj.org-article:357b300a7e434438a8ef0a890b5f4cb32021-12-02T14:21:56ZNon-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation10.1038/s41598-021-83270-52045-2322https://doaj.org/article/357b300a7e434438a8ef0a890b5f4cb32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83270-5https://doaj.org/toc/2045-2322Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitoring during cardiopulmonary resuscitation (CPR), and its predictive utility for return of spontaneous circulation (ROSC) in an established pediatric swine model of cardiac arrest. Cerebral tissue optical properties, oxy- and deoxy-hemoglobin concentration ([HbO2], [Hb]), oxygen saturation (StO2) and total hemoglobin concentration (THC) were measured by a FD-DOS probe placed on the forehead in 1-month-old swine (8–11 kg; n = 52) during seven minutes of asphyxiation followed by twenty minutes of CPR. ROSC prediction and time-dependent performance of prediction throughout early CPR (< 10 min), were assessed by the weighted Youden index (Jw, w = 0.1) with tenfold cross-validation. FD-DOS CPR data was successfully acquired in 48/52 animals; 37/48 achieved ROSC. Changes in scattering coefficient (785 nm), [HbO2], StO2 and THC from baseline were significantly different in ROSC versus No-ROSC subjects (p < 0.01) after 10 min of CPR. Change in [HbO2] of + 1.3 µmol/L from 1-min of CPR achieved the highest weighted Youden index (0.96) for ROSC prediction. We demonstrate feasibility of quantitative, non-invasive FD-DOS neuromonitoring, and stable, specific, early ROSC prediction from the third minute of CPR.Tiffany S. KoConstantine D. MavroudisRyan W. MorganWesley B. BakerAlexandra M. MarquezTimothy W. BooradyMahima DevarajanYuxi LinAnna L. RobertsWilliam P. LandisKobina Mensah-BrownVinay M. NadkarniRobert A. BergRobert M. SuttonArjun G. YodhDaniel J. LichtWensheng GuoTodd J. KilbaughNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiffany S. Ko Constantine D. Mavroudis Ryan W. Morgan Wesley B. Baker Alexandra M. Marquez Timothy W. Boorady Mahima Devarajan Yuxi Lin Anna L. Roberts William P. Landis Kobina Mensah-Brown Vinay M. Nadkarni Robert A. Berg Robert M. Sutton Arjun G. Yodh Daniel J. Licht Wensheng Guo Todd J. Kilbaugh Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
description	Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess the feasibility of quantitative, non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) neuromonitoring during cardiopulmonary resuscitation (CPR), and its predictive utility for return of spontaneous circulation (ROSC) in an established pediatric swine model of cardiac arrest. Cerebral tissue optical properties, oxy- and deoxy-hemoglobin concentration ([HbO2], [Hb]), oxygen saturation (StO2) and total hemoglobin concentration (THC) were measured by a FD-DOS probe placed on the forehead in 1-month-old swine (8–11 kg; n = 52) during seven minutes of asphyxiation followed by twenty minutes of CPR. ROSC prediction and time-dependent performance of prediction throughout early CPR (< 10 min), were assessed by the weighted Youden index (Jw, w = 0.1) with tenfold cross-validation. FD-DOS CPR data was successfully acquired in 48/52 animals; 37/48 achieved ROSC. Changes in scattering coefficient (785 nm), [HbO2], StO2 and THC from baseline were significantly different in ROSC versus No-ROSC subjects (p < 0.01) after 10 min of CPR. Change in [HbO2] of + 1.3 µmol/L from 1-min of CPR achieved the highest weighted Youden index (0.96) for ROSC prediction. We demonstrate feasibility of quantitative, non-invasive FD-DOS neuromonitoring, and stable, specific, early ROSC prediction from the third minute of CPR.
format	article
author	Tiffany S. Ko Constantine D. Mavroudis Ryan W. Morgan Wesley B. Baker Alexandra M. Marquez Timothy W. Boorady Mahima Devarajan Yuxi Lin Anna L. Roberts William P. Landis Kobina Mensah-Brown Vinay M. Nadkarni Robert A. Berg Robert M. Sutton Arjun G. Yodh Daniel J. Licht Wensheng Guo Todd J. Kilbaugh
author_facet	Tiffany S. Ko Constantine D. Mavroudis Ryan W. Morgan Wesley B. Baker Alexandra M. Marquez Timothy W. Boorady Mahima Devarajan Yuxi Lin Anna L. Roberts William P. Landis Kobina Mensah-Brown Vinay M. Nadkarni Robert A. Berg Robert M. Sutton Arjun G. Yodh Daniel J. Licht Wensheng Guo Todd J. Kilbaugh
author_sort	Tiffany S. Ko
title	Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
title_short	Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
title_full	Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
title_fullStr	Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
title_full_unstemmed	Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
title_sort	non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/357b300a7e434438a8ef0a890b5f4cb3
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Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation

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