Stressed Out About Plasmodium falciparum Gametocytogenesis

Blocking malaria transmission is critical to malaria control programs but remains a major challenge especially in endemic regions with high levels of asymptomatic infections. New strategies targeting the transmissible sexual stages of the parasite, called gametocytes, are needed. This review focuses...

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Autores principales:	Miho Usui, Kim C. Williamson
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	malaria transmission sexual differentiation gametocyte developmental regulation bone marrow Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/357e2f2a253d48f9b5299cd6ff8f2624
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spelling	oai:doaj.org-article:357e2f2a253d48f9b5299cd6ff8f26242021-12-02T10:25:47ZStressed Out About Plasmodium falciparum Gametocytogenesis2235-298810.3389/fcimb.2021.790067https://doaj.org/article/357e2f2a253d48f9b5299cd6ff8f26242021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.790067/fullhttps://doaj.org/toc/2235-2988Blocking malaria transmission is critical to malaria control programs but remains a major challenge especially in endemic regions with high levels of asymptomatic infections. New strategies targeting the transmissible sexual stages of the parasite, called gametocytes, are needed. This review focuses on P. falciparum gametocytogenesis in vivo and in vitro. Highlighting advances made elucidating genes required for gametocyte production and identifying key questions that remain unanswered such as the factors and regulatory mechanisms that contribute to gametocyte induction, and the mechanism of sequestration. Tools available to begin to address these issues are also described to facilitate advances in our understanding of this important stage of the life cycle.Miho UsuiKim C. WilliamsonFrontiers Media S.A.articlemalariatransmissionsexual differentiationgametocytedevelopmental regulationbone marrowMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malaria transmission sexual differentiation gametocyte developmental regulation bone marrow Microbiology QR1-502
spellingShingle	malaria transmission sexual differentiation gametocyte developmental regulation bone marrow Microbiology QR1-502 Miho Usui Kim C. Williamson Stressed Out About Plasmodium falciparum Gametocytogenesis
description	Blocking malaria transmission is critical to malaria control programs but remains a major challenge especially in endemic regions with high levels of asymptomatic infections. New strategies targeting the transmissible sexual stages of the parasite, called gametocytes, are needed. This review focuses on P. falciparum gametocytogenesis in vivo and in vitro. Highlighting advances made elucidating genes required for gametocyte production and identifying key questions that remain unanswered such as the factors and regulatory mechanisms that contribute to gametocyte induction, and the mechanism of sequestration. Tools available to begin to address these issues are also described to facilitate advances in our understanding of this important stage of the life cycle.
format	article
author	Miho Usui Kim C. Williamson
author_facet	Miho Usui Kim C. Williamson
author_sort	Miho Usui
title	Stressed Out About Plasmodium falciparum Gametocytogenesis
title_short	Stressed Out About Plasmodium falciparum Gametocytogenesis
title_full	Stressed Out About Plasmodium falciparum Gametocytogenesis
title_fullStr	Stressed Out About Plasmodium falciparum Gametocytogenesis
title_full_unstemmed	Stressed Out About Plasmodium falciparum Gametocytogenesis
title_sort	stressed out about plasmodium falciparum gametocytogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/357e2f2a253d48f9b5299cd6ff8f2624
work_keys_str_mv	AT mihousui stressedoutaboutplasmodiumfalciparumgametocytogenesis AT kimcwilliamson stressedoutaboutplasmodiumfalciparumgametocytogenesis
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Stressed Out About Plasmodium falciparum Gametocytogenesis

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