Genome-wide binding analysis of 195 DNA binding proteins reveals "reservoir" promoters and human specific SVA-repeat family regulation.

Genome-wide binding analysis of 195 DNA binding proteins reveals "reservoir" promoters and human specific SVA-repeat family regulation.

A key aspect in defining cell state is the complex choreography of DNA binding events in a given cell type, which in turn establishes a cell-specific gene-expression program. Here we wanted to take a deep analysis of DNA binding events and transcriptional output of a single cell state (K562 cells)....

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Autores principales: Michael J Smallegan, Soraya Shehata, Savannah F Spradlin, Alison Swearingen, Graycen Wheeler, Arpan Das, Giulia Corbet, Benjamin Nebenfuehr, Daniel Ahrens, Devin Tauber, Shelby Lennon, Kevin Choi, Thao Huynh, Tom Wieser, Kristen Schneider, Michael Bradshaw, Joel Basken, Maria Lai, Timothy Read, Matt Hynes-Grace, Dan Timmons, Jon Demasi, John L Rinn
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3581be7dbf384cbd93c22a41d69897a4
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