Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy

The zinc finger transcriptional repressor Prdm1/Blimp1 is essential for remodelling maternal blood vessels in a subset of trophoblast cells. Here, the authors perform single-cell RNA-seq analysis on this Blimp1+ lineage, identifying functionally distinct cell types present at the maternal–foetal int...

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Autores principales:	Andrew C. Nelson, Arne W. Mould, Elizabeth K. Bikoff, Elizabeth J. Robertson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/358498be65c14cc6abf10e9beb7b5ac5
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spelling	oai:doaj.org-article:358498be65c14cc6abf10e9beb7b5ac52021-12-02T16:56:46ZSingle-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy10.1038/ncomms114142041-1723https://doaj.org/article/358498be65c14cc6abf10e9beb7b5ac52016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11414https://doaj.org/toc/2041-1723The zinc finger transcriptional repressor Prdm1/Blimp1 is essential for remodelling maternal blood vessels in a subset of trophoblast cells. Here, the authors perform single-cell RNA-seq analysis on this Blimp1+ lineage, identifying functionally distinct cell types present at the maternal–foetal interface.Andrew C. NelsonArne W. MouldElizabeth K. BikoffElizabeth J. RobertsonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew C. Nelson Arne W. Mould Elizabeth K. Bikoff Elizabeth J. Robertson Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
description	The zinc finger transcriptional repressor Prdm1/Blimp1 is essential for remodelling maternal blood vessels in a subset of trophoblast cells. Here, the authors perform single-cell RNA-seq analysis on this Blimp1+ lineage, identifying functionally distinct cell types present at the maternal–foetal interface.
format	article
author	Andrew C. Nelson Arne W. Mould Elizabeth K. Bikoff Elizabeth J. Robertson
author_facet	Andrew C. Nelson Arne W. Mould Elizabeth K. Bikoff Elizabeth J. Robertson
author_sort	Andrew C. Nelson
title	Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
title_short	Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
title_full	Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
title_fullStr	Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
title_full_unstemmed	Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
title_sort	single-cell rna-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/358498be65c14cc6abf10e9beb7b5ac5
work_keys_str_mv	AT andrewcnelson singlecellrnaseqrevealscelltypespecifictranscriptionalsignaturesatthematernalfoetalinterfaceduringpregnancy AT arnewmould singlecellrnaseqrevealscelltypespecifictranscriptionalsignaturesatthematernalfoetalinterfaceduringpregnancy AT elizabethkbikoff singlecellrnaseqrevealscelltypespecifictranscriptionalsignaturesatthematernalfoetalinterfaceduringpregnancy AT elizabethjrobertson singlecellrnaseqrevealscelltypespecifictranscriptionalsignaturesatthematernalfoetalinterfaceduringpregnancy
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Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy

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