Functional Role of AKNA: A Scoping Review

Human <i>akna</i> encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping review on the literature regarding the functional role of AKNA according to the evidence found in human and in vivo and in vitro models, stringent...

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Autores principales:	Abrahán Ramírez-González, Joaquín Manzo-Merino, Carla Olbia Contreras-Ochoa, Margarita Bahena-Román, José Manasés Aguilar-Villaseñor, Alfredo Lagunas-Martínez, Yvonne Rosenstein, Vicente Madrid Marina, Kirvis Torres-Poveda
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	AKNA function immune response inflammation autoimmunity cancer Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3589f2645a554f6298265cd997a16ae8
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spelling	oai:doaj.org-article:3589f2645a554f6298265cd997a16ae82021-11-25T16:54:07ZFunctional Role of AKNA: A Scoping Review10.3390/biom111117092218-273Xhttps://doaj.org/article/3589f2645a554f6298265cd997a16ae82021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1709https://doaj.org/toc/2218-273XHuman <i>akna</i> encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping review on the literature regarding the functional role of AKNA according to the evidence found in human and in vivo and in vitro models, stringently following the “PRISMA-ScR” statement recommendations. Methods: We undertook an independent PubMed literature search using the following search terms, AKNA OR AKNA ADJ gene OR AKNA protein, human OR AKNA ADJ functions. Observational and experimental articles were considered. The selected studies were categorized using a pre-determined data extraction form. A narrative summary of the evidence was produced. Results: AKNA modulates the expression of CD40 and CD40L genes in immune system cells. It is a negative regulator of inflammatory processes as evidenced by knockout mouse models and observational studies for several autoimmune and inflammatory diseases. Furthermore, AKNA contributes to the de-regulation of the immune system in cancer, and it has been proposed as a susceptibility genetic factor and biomarker in CC, GC, and HNSCC. Finally, AKNA regulates neurogenesis by destabilizing the microtubules dynamics. Conclusion: Our results provide evidence for the role of AKNA in various cellular processes, including immune response, inflammation, development, cancer, autoimmunity, and neurogenesis.Abrahán Ramírez-GonzálezJoaquín Manzo-MerinoCarla Olbia Contreras-OchoaMargarita Bahena-RománJosé Manasés Aguilar-VillaseñorAlfredo Lagunas-MartínezYvonne RosensteinVicente Madrid MarinaKirvis Torres-PovedaMDPI AGarticleAKNAfunctionimmune responseinflammationautoimmunitycancerMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1709, p 1709 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AKNA function immune response inflammation autoimmunity cancer Microbiology QR1-502
spellingShingle	AKNA function immune response inflammation autoimmunity cancer Microbiology QR1-502 Abrahán Ramírez-González Joaquín Manzo-Merino Carla Olbia Contreras-Ochoa Margarita Bahena-Román José Manasés Aguilar-Villaseñor Alfredo Lagunas-Martínez Yvonne Rosenstein Vicente Madrid Marina Kirvis Torres-Poveda Functional Role of AKNA: A Scoping Review
description	Human <i>akna</i> encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping review on the literature regarding the functional role of AKNA according to the evidence found in human and in vivo and in vitro models, stringently following the “PRISMA-ScR” statement recommendations. Methods: We undertook an independent PubMed literature search using the following search terms, AKNA OR AKNA ADJ gene OR AKNA protein, human OR AKNA ADJ functions. Observational and experimental articles were considered. The selected studies were categorized using a pre-determined data extraction form. A narrative summary of the evidence was produced. Results: AKNA modulates the expression of CD40 and CD40L genes in immune system cells. It is a negative regulator of inflammatory processes as evidenced by knockout mouse models and observational studies for several autoimmune and inflammatory diseases. Furthermore, AKNA contributes to the de-regulation of the immune system in cancer, and it has been proposed as a susceptibility genetic factor and biomarker in CC, GC, and HNSCC. Finally, AKNA regulates neurogenesis by destabilizing the microtubules dynamics. Conclusion: Our results provide evidence for the role of AKNA in various cellular processes, including immune response, inflammation, development, cancer, autoimmunity, and neurogenesis.
format	article
author	Abrahán Ramírez-González Joaquín Manzo-Merino Carla Olbia Contreras-Ochoa Margarita Bahena-Román José Manasés Aguilar-Villaseñor Alfredo Lagunas-Martínez Yvonne Rosenstein Vicente Madrid Marina Kirvis Torres-Poveda
author_facet	Abrahán Ramírez-González Joaquín Manzo-Merino Carla Olbia Contreras-Ochoa Margarita Bahena-Román José Manasés Aguilar-Villaseñor Alfredo Lagunas-Martínez Yvonne Rosenstein Vicente Madrid Marina Kirvis Torres-Poveda
author_sort	Abrahán Ramírez-González
title	Functional Role of AKNA: A Scoping Review
title_short	Functional Role of AKNA: A Scoping Review
title_full	Functional Role of AKNA: A Scoping Review
title_fullStr	Functional Role of AKNA: A Scoping Review
title_full_unstemmed	Functional Role of AKNA: A Scoping Review
title_sort	functional role of akna: a scoping review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3589f2645a554f6298265cd997a16ae8
work_keys_str_mv	AT abrahanramirezgonzalez functionalroleofaknaascopingreview AT joaquinmanzomerino functionalroleofaknaascopingreview AT carlaolbiacontrerasochoa functionalroleofaknaascopingreview AT margaritabahenaroman functionalroleofaknaascopingreview AT josemanasesaguilarvillasenor functionalroleofaknaascopingreview AT alfredolagunasmartinez functionalroleofaknaascopingreview AT yvonnerosenstein functionalroleofaknaascopingreview AT vicentemadridmarina functionalroleofaknaascopingreview AT kirvistorrespoveda functionalroleofaknaascopingreview
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Functional Role of AKNA: A Scoping Review

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