Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and p...
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Nature Portfolio
2018
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oai:doaj.org-article:358b10958e814ff3ae9b2917b6e35d5b2021-12-02T17:31:12ZElucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing10.1038/s41467-017-02584-z2041-1723https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02584-zhttps://doaj.org/toc/2041-1723EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.Rahul NaharWeiwei ZhaiTong ZhangAngela TakanoAlexis J. KhngYin Yeng LeeXingliang LiuChong Hee LimTina P. T. KohZaw Win AungTony Kiat Hon LimLavanya VeeravalliJu YuanAudrey S. M. TeoCheryl X. ChanHuay Mei PohIvan M. L. ChuaAudrey Ann LiewDawn Ping Xi LauXue Lin KwangChee Keong TohWan-Teck LimBing LimWai Leong TamEng-Huat TanAxel M. HillmerDaniel S. W. TanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Rahul Nahar Weiwei Zhai Tong Zhang Angela Takano Alexis J. Khng Yin Yeng Lee Xingliang Liu Chong Hee Lim Tina P. T. Koh Zaw Win Aung Tony Kiat Hon Lim Lavanya Veeravalli Ju Yuan Audrey S. M. Teo Cheryl X. Chan Huay Mei Poh Ivan M. L. Chua Audrey Ann Liew Dawn Ping Xi Lau Xue Lin Kwang Chee Keong Toh Wan-Teck Lim Bing Lim Wai Leong Tam Eng-Huat Tan Axel M. Hillmer Daniel S. W. Tan Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| description |
EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance. |
| format |
article |
| author |
Rahul Nahar Weiwei Zhai Tong Zhang Angela Takano Alexis J. Khng Yin Yeng Lee Xingliang Liu Chong Hee Lim Tina P. T. Koh Zaw Win Aung Tony Kiat Hon Lim Lavanya Veeravalli Ju Yuan Audrey S. M. Teo Cheryl X. Chan Huay Mei Poh Ivan M. L. Chua Audrey Ann Liew Dawn Ping Xi Lau Xue Lin Kwang Chee Keong Toh Wan-Teck Lim Bing Lim Wai Leong Tam Eng-Huat Tan Axel M. Hillmer Daniel S. W. Tan |
| author_facet |
Rahul Nahar Weiwei Zhai Tong Zhang Angela Takano Alexis J. Khng Yin Yeng Lee Xingliang Liu Chong Hee Lim Tina P. T. Koh Zaw Win Aung Tony Kiat Hon Lim Lavanya Veeravalli Ju Yuan Audrey S. M. Teo Cheryl X. Chan Huay Mei Poh Ivan M. L. Chua Audrey Ann Liew Dawn Ping Xi Lau Xue Lin Kwang Chee Keong Toh Wan-Teck Lim Bing Lim Wai Leong Tam Eng-Huat Tan Axel M. Hillmer Daniel S. W. Tan |
| author_sort |
Rahul Nahar |
| title |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| title_short |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| title_full |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| title_fullStr |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| title_full_unstemmed |
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing |
| title_sort |
elucidating the genomic architecture of asian egfr-mutant lung adenocarcinoma through multi-region exome sequencing |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b |
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