Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the binding site of the competitive inhibitor CI-976.

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Autores principales:	Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, Tuoping Luo, Lei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/358be672ffd24c55bc5303397e78ae42
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spelling	oai:doaj.org-article:358be672ffd24c55bc5303397e78ae422021-12-02T16:51:34ZStructural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor10.1038/s41467-020-16288-42041-1723https://doaj.org/article/358be672ffd24c55bc5303397e78ae422020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16288-4https://doaj.org/toc/2041-1723Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the binding site of the competitive inhibitor CI-976.Chengcheng GuanYange NiuSi-Cong ChenYunlu KangJing-Xiang WuKoji NishiCatherine C. Y. ChangTa-Yuan ChangTuoping LuoLei ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chengcheng Guan Yange Niu Si-Cong Chen Yunlu Kang Jing-Xiang Wu Koji Nishi Catherine C. Y. Chang Ta-Yuan Chang Tuoping Luo Lei Chen Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
description	Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the binding site of the competitive inhibitor CI-976.
format	article
author	Chengcheng Guan Yange Niu Si-Cong Chen Yunlu Kang Jing-Xiang Wu Koji Nishi Catherine C. Y. Chang Ta-Yuan Chang Tuoping Luo Lei Chen
author_facet	Chengcheng Guan Yange Niu Si-Cong Chen Yunlu Kang Jing-Xiang Wu Koji Nishi Catherine C. Y. Chang Ta-Yuan Chang Tuoping Luo Lei Chen
author_sort	Chengcheng Guan
title	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
title_short	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
title_full	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
title_fullStr	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
title_full_unstemmed	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
title_sort	structural insights into the inhibition mechanism of human sterol o-acyltransferase 1 by a competitive inhibitor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/358be672ffd24c55bc5303397e78ae42
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Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

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