Significant association between parathyroid hormone and uric acid level in men

Kok-Yong Chin,1 Soelaiman Ima Nirwana,1 Wan Zurinah Wan Ngah21Department of Pharmacology, 2Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaBackground: Previous reports of patients undergoing parathyroidectomy and of patients recei...

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Autores principales:	Chin KY, Ima Nirwana S, Wan Ngah WZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Hyperuricemia men parathyroid hormone uric acid urate Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/358c6624c7d64b21bf3957eb58d4e94a
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spelling	oai:doaj.org-article:358c6624c7d64b21bf3957eb58d4e94a2021-12-02T07:15:30ZSignificant association between parathyroid hormone and uric acid level in men1178-1998https://doaj.org/article/358c6624c7d64b21bf3957eb58d4e94a2015-08-01T00:00:00Zhttps://www.dovepress.com/significant-association-between-parathyroid-hormone-and-uric-acid-leve-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Kok-Yong Chin,1 Soelaiman Ima Nirwana,1 Wan Zurinah Wan Ngah21Department of Pharmacology, 2Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaBackground: Previous reports of patients undergoing parathyroidectomy and of patients receiving teriparatide as antiosteoporotic treatment have suggested a plausible relationship between parathyroid hormone (PTH) and uric acid. However, similar data at population level were lacking. The current study aimed to determine the relationship between PTH and uric acid in a group of apparently healthy Malaysian men.Methods: A cross-sectional study was conducted among 380 Malay and Chinese men aged 20 years and above, residing in the Klang Valley, Malaysia. Their body anthropometry was measured, and their fasting blood samples were collected for biochemical analysis. The relationship between PTH and uric acid was analyzed using regression analysis.Results: Increased serum PTH level was significantly associated with increased serum uric acid level (β=0.165; P=0.001). Increased PTH level was also significantly associated with the condition of hyperuricemia in the study population (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.017–1.075; P=0.002). All analyses were adjusted for age, body mass index, vitamin D, total calcium, inorganic phosphate, blood urea nitrogen and creatinine levels.Conclusion: There is a significant positive relationship between PTH level and uric acid level in Malaysian men. This relationship and its clinical significance should be further investigated in a larger longitudinal study. Keywords: hyperuricemia, Asian, cross-sectional study, uric acid, urateChin KYIma Nirwana SWan Ngah WZDove Medical PressarticleHyperuricemiamenparathyroid hormoneuric acidurateGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 1377-1380 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hyperuricemia men parathyroid hormone uric acid urate Geriatrics RC952-954.6
spellingShingle	Hyperuricemia men parathyroid hormone uric acid urate Geriatrics RC952-954.6 Chin KY Ima Nirwana S Wan Ngah WZ Significant association between parathyroid hormone and uric acid level in men
description	Kok-Yong Chin,1 Soelaiman Ima Nirwana,1 Wan Zurinah Wan Ngah21Department of Pharmacology, 2Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaBackground: Previous reports of patients undergoing parathyroidectomy and of patients receiving teriparatide as antiosteoporotic treatment have suggested a plausible relationship between parathyroid hormone (PTH) and uric acid. However, similar data at population level were lacking. The current study aimed to determine the relationship between PTH and uric acid in a group of apparently healthy Malaysian men.Methods: A cross-sectional study was conducted among 380 Malay and Chinese men aged 20 years and above, residing in the Klang Valley, Malaysia. Their body anthropometry was measured, and their fasting blood samples were collected for biochemical analysis. The relationship between PTH and uric acid was analyzed using regression analysis.Results: Increased serum PTH level was significantly associated with increased serum uric acid level (β=0.165; P=0.001). Increased PTH level was also significantly associated with the condition of hyperuricemia in the study population (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.017–1.075; P=0.002). All analyses were adjusted for age, body mass index, vitamin D, total calcium, inorganic phosphate, blood urea nitrogen and creatinine levels.Conclusion: There is a significant positive relationship between PTH level and uric acid level in Malaysian men. This relationship and its clinical significance should be further investigated in a larger longitudinal study. Keywords: hyperuricemia, Asian, cross-sectional study, uric acid, urate
format	article
author	Chin KY Ima Nirwana S Wan Ngah WZ
author_facet	Chin KY Ima Nirwana S Wan Ngah WZ
author_sort	Chin KY
title	Significant association between parathyroid hormone and uric acid level in men
title_short	Significant association between parathyroid hormone and uric acid level in men
title_full	Significant association between parathyroid hormone and uric acid level in men
title_fullStr	Significant association between parathyroid hormone and uric acid level in men
title_full_unstemmed	Significant association between parathyroid hormone and uric acid level in men
title_sort	significant association between parathyroid hormone and uric acid level in men
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/358c6624c7d64b21bf3957eb58d4e94a
work_keys_str_mv	AT chinky significantassociationbetweenparathyroidhormoneanduricacidlevelinmen AT imanirwanas significantassociationbetweenparathyroidhormoneanduricacidlevelinmen AT wanngahwz significantassociationbetweenparathyroidhormoneanduricacidlevelinmen
_version_	1718399511036952576

Significant association between parathyroid hormone and uric acid level in men

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