An Avian H7N1 Gain-of-Function Experiment of Great Concern
ABSTRACT Inappropriately named gain-of-function influenza research seeks to confer airborne transmission on avian influenza A viruses that otherwise cause only dead-end infections in humans. A recent study has succeeded in doing this with a highly pathogenic ostrich H7N1 virus in a ferret model with...
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American Society for Microbiology
2014
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oai:doaj.org-article:358c671b1d944ecaaf56ba2d8915ae612021-11-15T15:45:55ZAn Avian H7N1 Gain-of-Function Experiment of Great Concern10.1128/mBio.01882-142150-7511https://doaj.org/article/358c671b1d944ecaaf56ba2d8915ae612014-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01882-14https://doaj.org/toc/2150-7511ABSTRACT Inappropriately named gain-of-function influenza research seeks to confer airborne transmission on avian influenza A viruses that otherwise cause only dead-end infections in humans. A recent study has succeeded in doing this with a highly pathogenic ostrich H7N1 virus in a ferret model without loss of virulence. If transposable to humans, this would constitute a novel virus with a case fatality rate ~30 greater than that of Spanish flu. A commentary from three distinguished virologists considered the benefits of this work to outweigh potential risks. I beg to disagree with conclusions in both papers, for the underlying science is not as strong as it appears.Simon Wain-HobsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 5 (2014) |
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DOAJ |
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DOAJ |
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EN |
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Microbiology QR1-502 |
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Microbiology QR1-502 Simon Wain-Hobson An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| description |
ABSTRACT Inappropriately named gain-of-function influenza research seeks to confer airborne transmission on avian influenza A viruses that otherwise cause only dead-end infections in humans. A recent study has succeeded in doing this with a highly pathogenic ostrich H7N1 virus in a ferret model without loss of virulence. If transposable to humans, this would constitute a novel virus with a case fatality rate ~30 greater than that of Spanish flu. A commentary from three distinguished virologists considered the benefits of this work to outweigh potential risks. I beg to disagree with conclusions in both papers, for the underlying science is not as strong as it appears. |
| format |
article |
| author |
Simon Wain-Hobson |
| author_facet |
Simon Wain-Hobson |
| author_sort |
Simon Wain-Hobson |
| title |
An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| title_short |
An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| title_full |
An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| title_fullStr |
An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| title_full_unstemmed |
An Avian H7N1 Gain-of-Function Experiment of Great Concern |
| title_sort |
avian h7n1 gain-of-function experiment of great concern |
| publisher |
American Society for Microbiology |
| publishDate |
2014 |
| url |
https://doaj.org/article/358c671b1d944ecaaf56ba2d8915ae61 |
| work_keys_str_mv |
AT simonwainhobson anavianh7n1gainoffunctionexperimentofgreatconcern AT simonwainhobson avianh7n1gainoffunctionexperimentofgreatconcern |
| _version_ |
1718427508861304832 |