IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumo...

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Autores principales:	Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be
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spelling	oai:doaj.org-article:358dfe59c0ac41659d29059d99a2f0be2021-12-02T15:35:34ZIL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization10.1038/s41467-019-10676-12041-1723https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10676-1https://doaj.org/toc/2041-1723Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.Moritz F. EissmannChristine DijkstraAndrew JarnickiToby PhesseJamina BrunnbergAshleigh R. PohNima EtemadiEvelyn TsantikosStefan ThiemNicholas D. HuntingtonMargaret L. HibbsAlex BoussioutasMichele A. GrimbaldestonMichael BuchertRobert J. J. O’DonoghueFrederick MassonMatthias ErnstNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
description	Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.
format	article
author	Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst
author_facet	Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst
author_sort	Moritz F. Eissmann
title	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_short	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_full	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_fullStr	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_full_unstemmed	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_sort	il-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be
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IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

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