Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines

Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors developed a novel imaging approach to monitor...

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Autores principales:	Jui-Yun Chang, Yoshihisa Nakahata, Yuki Hayano, Ryohei Yasuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/358e92de3d6447b79eadba0aee916381
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spelling	oai:doaj.org-article:358e92de3d6447b79eadba0aee9163812021-12-02T16:50:57ZMechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines10.1038/s41467-019-10694-z2041-1723https://doaj.org/article/358e92de3d6447b79eadba0aee9163812019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10694-zhttps://doaj.org/toc/2041-1723Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors developed a novel imaging approach to monitor CaM interactions CaMKIIα in cultured hippocampal neurons after uncaging of glutamate. This allowed the authors to model the kinetics of CaMKIIα activation in single dendritic spines.Jui-Yun ChangYoshihisa NakahataYuki HayanoRyohei YasudaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jui-Yun Chang Yoshihisa Nakahata Yuki Hayano Ryohei Yasuda Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
description	Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors developed a novel imaging approach to monitor CaM interactions CaMKIIα in cultured hippocampal neurons after uncaging of glutamate. This allowed the authors to model the kinetics of CaMKIIα activation in single dendritic spines.
format	article
author	Jui-Yun Chang Yoshihisa Nakahata Yuki Hayano Ryohei Yasuda
author_facet	Jui-Yun Chang Yoshihisa Nakahata Yuki Hayano Ryohei Yasuda
author_sort	Jui-Yun Chang
title	Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
title_short	Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
title_full	Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
title_fullStr	Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
title_full_unstemmed	Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
title_sort	mechanisms of ca2+/calmodulin-dependent kinase ii activation in single dendritic spines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/358e92de3d6447b79eadba0aee916381
work_keys_str_mv	AT juiyunchang mechanismsofca2calmodulindependentkinaseiiactivationinsingledendriticspines AT yoshihisanakahata mechanismsofca2calmodulindependentkinaseiiactivationinsingledendriticspines AT yukihayano mechanismsofca2calmodulindependentkinaseiiactivationinsingledendriticspines AT ryoheiyasuda mechanismsofca2calmodulindependentkinaseiiactivationinsingledendriticspines
_version_	1718382969944539136

Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines

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