Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study

Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants o...

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Autores principales:	Hayoung Choi, Jung Eun Yoo, Kyungdo Han, Wonsuk Choi, Sang Youl Rhee, Hyun Lee, Dong Wook Shin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetes mellitus tuberculosis body mass index epidemiology nutritional status Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/359607652d714e7aa49c4d767cd39b92
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spelling	oai:doaj.org-article:359607652d714e7aa49c4d767cd39b922021-12-01T23:17:32ZBody Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study2296-861X10.3389/fnut.2021.739766https://doaj.org/article/359607652d714e7aa49c4d767cd39b922021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.739766/fullhttps://doaj.org/toc/2296-861XAlthough both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants of the Korean National Health Screening Program in 2009. The cohort was followed up to the date of TB incidence, death, or until December 31, 2018. We compared the incidence and risk of TB according to BMI category and DM. During the 7.3-year follow-up duration, the incidence of TB was 0.92 per 1,000 person-years in the normal weight without DM, 2.26 in the normal weight with DM, 1.80 in the underweight without DM, and 5.35 in the underweight with DM. Compared to the normal weight without DM, the normal weight with DM, the underweight without DM, and the underweight with DM showed a 1.51-fold (95% CI, 1.46–1.57), a 2.21-fold (95% CI, 2.14–2.28), and a 3.24-fold (95% CI, 2.95–3.56) increased risk of TB, respectively. However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36–0.38) and a 0.42 (95% CI, 0.36–0.48)-fold decreased risk of TB, respectively. There was no significant joint effect of BMI and DM on the risk of incident TB in the overall population; a synergistic effect of underweight and DM was evident in participants <65 years of age, current smokers, and heavy drinkers. In conclusion, being underweight or DM individually increases the risk of incident TB. Based on our study results, a focused screening of incident TB in patients with DM may be beneficial.Hayoung ChoiJung Eun YooKyungdo HanWonsuk ChoiSang Youl RheeHyun LeeDong Wook ShinDong Wook ShinFrontiers Media S.A.articlediabetes mellitustuberculosisbody mass indexepidemiologynutritional statusNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus tuberculosis body mass index epidemiology nutritional status Nutrition. Foods and food supply TX341-641
spellingShingle	diabetes mellitus tuberculosis body mass index epidemiology nutritional status Nutrition. Foods and food supply TX341-641 Hayoung Choi Jung Eun Yoo Kyungdo Han Wonsuk Choi Sang Youl Rhee Hyun Lee Dong Wook Shin Dong Wook Shin Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
description	Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously—body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants of the Korean National Health Screening Program in 2009. The cohort was followed up to the date of TB incidence, death, or until December 31, 2018. We compared the incidence and risk of TB according to BMI category and DM. During the 7.3-year follow-up duration, the incidence of TB was 0.92 per 1,000 person-years in the normal weight without DM, 2.26 in the normal weight with DM, 1.80 in the underweight without DM, and 5.35 in the underweight with DM. Compared to the normal weight without DM, the normal weight with DM, the underweight without DM, and the underweight with DM showed a 1.51-fold (95% CI, 1.46–1.57), a 2.21-fold (95% CI, 2.14–2.28), and a 3.24-fold (95% CI, 2.95–3.56) increased risk of TB, respectively. However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36–0.38) and a 0.42 (95% CI, 0.36–0.48)-fold decreased risk of TB, respectively. There was no significant joint effect of BMI and DM on the risk of incident TB in the overall population; a synergistic effect of underweight and DM was evident in participants <65 years of age, current smokers, and heavy drinkers. In conclusion, being underweight or DM individually increases the risk of incident TB. Based on our study results, a focused screening of incident TB in patients with DM may be beneficial.
format	article
author	Hayoung Choi Jung Eun Yoo Kyungdo Han Wonsuk Choi Sang Youl Rhee Hyun Lee Dong Wook Shin Dong Wook Shin
author_facet	Hayoung Choi Jung Eun Yoo Kyungdo Han Wonsuk Choi Sang Youl Rhee Hyun Lee Dong Wook Shin Dong Wook Shin
author_sort	Hayoung Choi
title	Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
title_short	Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
title_full	Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
title_fullStr	Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
title_full_unstemmed	Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study
title_sort	body mass index, diabetes, and risk of tuberculosis: a retrospective cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/359607652d714e7aa49c4d767cd39b92
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Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study

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