NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES

Autoantibodies are well-established biomarkers of autoimmune rheumatic diseases. Their detection in the routine clinical laboratory provides key information for early and differential diagnosis, prognosis, and monitoring of disease-activity. However, the currently existing variety of laboratory test...

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Autores principales:	D. Roggenbuck, P. Schierac, U. Sack, S. V. Lapin, A. V. Mazing, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoantibody rheumatic diseases standardization laboratory diagnostics Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/35962fd44c574619bcce3346147b259a
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spelling	oai:doaj.org-article:35962fd44c574619bcce3346147b259a2021-11-18T08:03:44ZNOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES1563-06252313-741X10.15789/1563-0625-2014-3-221-226https://doaj.org/article/35962fd44c574619bcce3346147b259a2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/687https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAutoantibodies are well-established biomarkers of autoimmune rheumatic diseases. Their detection in the routine clinical laboratory provides key information for early and differential diagnosis, prognosis, and monitoring of disease-activity. However, the currently existing variety of laboratory tests and methods as well as different diagnostic and clinical algorithms of autoimmune testing is the reason for lack of reproducibility and harmonization across immunological laboratories. Novel technical developments in the area of digital analysis of immunofluorescent images paved the way for the improvement of intra- and interlaboratory standardizationof test results. Additionally, digital immunofluorescence analysis enables the simultaneous multiparametric combination of cell- or tissue-based indirect immunofluorescence screening tests with confirmatory testing employing microparticles covered with purified autoantigens in one reaction environment.D. RoggenbuckP. SchieracU. SackS. V. LapinA. V. MazingAreg A. TotolianSPb RAACIarticleautoantibodyrheumatic diseasesstandardizationlaboratory diagnosticsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 221-226 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibody rheumatic diseases standardization laboratory diagnostics Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibody rheumatic diseases standardization laboratory diagnostics Immunologic diseases. Allergy RC581-607 D. Roggenbuck P. Schierac U. Sack S. V. Lapin A. V. Mazing Areg A. Totolian NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
description	Autoantibodies are well-established biomarkers of autoimmune rheumatic diseases. Their detection in the routine clinical laboratory provides key information for early and differential diagnosis, prognosis, and monitoring of disease-activity. However, the currently existing variety of laboratory tests and methods as well as different diagnostic and clinical algorithms of autoimmune testing is the reason for lack of reproducibility and harmonization across immunological laboratories. Novel technical developments in the area of digital analysis of immunofluorescent images paved the way for the improvement of intra- and interlaboratory standardizationof test results. Additionally, digital immunofluorescence analysis enables the simultaneous multiparametric combination of cell- or tissue-based indirect immunofluorescence screening tests with confirmatory testing employing microparticles covered with purified autoantigens in one reaction environment.
format	article
author	D. Roggenbuck P. Schierac U. Sack S. V. Lapin A. V. Mazing Areg A. Totolian
author_facet	D. Roggenbuck P. Schierac U. Sack S. V. Lapin A. V. Mazing Areg A. Totolian
author_sort	D. Roggenbuck
title	NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
title_short	NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
title_full	NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
title_fullStr	NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
title_full_unstemmed	NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES
title_sort	novel methods for autoantibody detection in laboratory diagnostics of autoimmune rheumatic diseases
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/35962fd44c574619bcce3346147b259a
work_keys_str_mv	AT droggenbuck novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases AT pschierac novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases AT usack novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases AT svlapin novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases AT avmazing novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases AT aregatotolian novelmethodsforautoantibodydetectioninlaboratorydiagnosticsofautoimmunerheumaticdiseases
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NOVEL METHODS FOR AUTOANTIBODY DETECTION IN LABORATORY DIAGNOSTICS OF AUTOIMMUNE RHEUMATIC DISEASES

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