A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora

<b>Background:</b> An estimated 75% of women will have one episode of vulvovaginal candidiasis (VCC) during their lifetime, and 40–50% of these will experience further episodes. The high incidence of vulvovaginal candidiasis, combined with the problems of azole resistance and toxicity, h...

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Autores principales:	Guglielmo Stabile, Roberta Marie Gentile, Stefania Carlucci, Stefano Restaino, Francesco De Seta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vulvovaginal candidiasis treatment therapy probiotics vaginal flora clotrimazole Medicine R
Acceso en línea:	https://doaj.org/article/3597418ba56544409a43370f66c1ebd6
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spelling	oai:doaj.org-article:3597418ba56544409a43370f66c1ebd62021-11-25T17:46:11ZA New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora10.3390/healthcare91115552227-9032https://doaj.org/article/3597418ba56544409a43370f66c1ebd62021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1555https://doaj.org/toc/2227-9032<b>Background:</b> An estimated 75% of women will have one episode of vulvovaginal candidiasis (VCC) during their lifetime, and 40–50% of these will experience further episodes. The high incidence of vulvovaginal candidiasis, combined with the problems of azole resistance and toxicity, highlights the necessity for new strategies for the treatment of this condition. In this context, natural compounds represent promising alternatives. <b>Methods:</b> We enrolled, between January 2020 and April 2021, forty women affected by uncomplicated vulvovaginal candidiasis. Women were divided into two groups. In the first group, we treated 20 women with clotrimazole daily administration for six days. In the second group, 20 women were treated with clotrimazole associated with Unilen<sup>®</sup> Microbio+, a new product containing <i>Saccharomyces cerevisiae</i>, melatonin, and GLA-14. Women underwent a check at days 15, 30, and 90. A clinical and cultural examination were performed to establish the effect of the treatments on vaginal flora. <b>Results:</b> In the group treated with Unilen<sup>®</sup> Microbio+, clinical and microbiological cure at 15 and 30 days was observed in 18 women (90%), compared with 16 women (80%) in the group treated only with clotrimazole. The efficacy of the association between clotrimazole and Unilen<sup>®</sup> Microbio+ in these uncomplicated forms was therefore not inferior to the azole treatment alone. Only four women (20%) in the Unilen<sup>®</sup> Microbio+ group presented symptomatic recurrences within the 3 months, compared with eight women (40%) in the clotrimazole-only group. Microscopic wet mount analysis at 1 and 3 months demonstrated a significant increase in lactobacillus count and a reduction in the polymorphonucleate cells in the Unilen<sup>®</sup> Microbio+ group. <b>Conclusions:</b> Unilen<sup>®</sup> Microbio+ supplementation was demonstrated to cure uncomplicated vulvovaginal candidiasis with clotrimazole, reducing recurrence and improving vaginal flora better than clotrimazole treatment alone.Guglielmo StabileRoberta Marie GentileStefania CarlucciStefano RestainoFrancesco De SetaMDPI AGarticlevulvovaginal candidiasistreatmenttherapyprobioticsvaginal floraclotrimazoleMedicineRENHealthcare, Vol 9, Iss 1555, p 1555 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vulvovaginal candidiasis treatment therapy probiotics vaginal flora clotrimazole Medicine R
spellingShingle	vulvovaginal candidiasis treatment therapy probiotics vaginal flora clotrimazole Medicine R Guglielmo Stabile Roberta Marie Gentile Stefania Carlucci Stefano Restaino Francesco De Seta A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
description	<b>Background:</b> An estimated 75% of women will have one episode of vulvovaginal candidiasis (VCC) during their lifetime, and 40–50% of these will experience further episodes. The high incidence of vulvovaginal candidiasis, combined with the problems of azole resistance and toxicity, highlights the necessity for new strategies for the treatment of this condition. In this context, natural compounds represent promising alternatives. <b>Methods:</b> We enrolled, between January 2020 and April 2021, forty women affected by uncomplicated vulvovaginal candidiasis. Women were divided into two groups. In the first group, we treated 20 women with clotrimazole daily administration for six days. In the second group, 20 women were treated with clotrimazole associated with Unilen<sup>®</sup> Microbio+, a new product containing <i>Saccharomyces cerevisiae</i>, melatonin, and GLA-14. Women underwent a check at days 15, 30, and 90. A clinical and cultural examination were performed to establish the effect of the treatments on vaginal flora. <b>Results:</b> In the group treated with Unilen<sup>®</sup> Microbio+, clinical and microbiological cure at 15 and 30 days was observed in 18 women (90%), compared with 16 women (80%) in the group treated only with clotrimazole. The efficacy of the association between clotrimazole and Unilen<sup>®</sup> Microbio+ in these uncomplicated forms was therefore not inferior to the azole treatment alone. Only four women (20%) in the Unilen<sup>®</sup> Microbio+ group presented symptomatic recurrences within the 3 months, compared with eight women (40%) in the clotrimazole-only group. Microscopic wet mount analysis at 1 and 3 months demonstrated a significant increase in lactobacillus count and a reduction in the polymorphonucleate cells in the Unilen<sup>®</sup> Microbio+ group. <b>Conclusions:</b> Unilen<sup>®</sup> Microbio+ supplementation was demonstrated to cure uncomplicated vulvovaginal candidiasis with clotrimazole, reducing recurrence and improving vaginal flora better than clotrimazole treatment alone.
format	article
author	Guglielmo Stabile Roberta Marie Gentile Stefania Carlucci Stefano Restaino Francesco De Seta
author_facet	Guglielmo Stabile Roberta Marie Gentile Stefania Carlucci Stefano Restaino Francesco De Seta
author_sort	Guglielmo Stabile
title	A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
title_short	A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
title_full	A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
title_fullStr	A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
title_full_unstemmed	A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
title_sort	new therapy for uncomplicated vulvovaginal candidiasis and its impact on vaginal flora
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3597418ba56544409a43370f66c1ebd6
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A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora

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