Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

Water balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected. Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angela Kim, Joseph C Madara, Chen Wu, Mark L Andermann, Bradford B Lowell
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	vasopressin presystemic feedforward osmolality water balance fiber photometry Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/359807ebee8d4f77897ed1da66bf84ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:359807ebee8d4f77897ed1da66bf84ec
record_format	dspace
spelling	oai:doaj.org-article:359807ebee8d4f77897ed1da66bf84ec2021-11-18T12:54:00ZNeural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality10.7554/eLife.666092050-084Xe66609https://doaj.org/article/359807ebee8d4f77897ed1da66bf84ec2021-09-01T00:00:00Zhttps://elifesciences.org/articles/66609https://doaj.org/toc/2050-084XWater balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected. Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated. Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion. AVP neurons are under feedback and feedforward regulation. Not only do they respond to disturbances in blood osmolality, but they are also rapidly suppressed and stimulated, respectively, by drinking and eating, which will ultimately decrease and increase osmolality. Here, we demonstrate that AVP neuron activity is regulated by multiple anatomically and functionally distinct neural circuits. Notably, presystemic regulation during drinking and eating are mediated by non-overlapping circuits that involve the lamina terminalis and hypothalamic arcuate nucleus, respectively. These findings reveal neural mechanisms that support differential regulation of AVP release by diverse behavioral and physiological stimuli.Angela KimJoseph C MadaraChen WuMark L AndermannBradford B LowelleLife Sciences Publications Ltdarticlevasopressinpresystemicfeedforwardosmolalitywater balancefiber photometryMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vasopressin presystemic feedforward osmolality water balance fiber photometry Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	vasopressin presystemic feedforward osmolality water balance fiber photometry Medicine R Science Q Biology (General) QH301-705.5 Angela Kim Joseph C Madara Chen Wu Mark L Andermann Bradford B Lowell Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
description	Water balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected. Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated. Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion. AVP neurons are under feedback and feedforward regulation. Not only do they respond to disturbances in blood osmolality, but they are also rapidly suppressed and stimulated, respectively, by drinking and eating, which will ultimately decrease and increase osmolality. Here, we demonstrate that AVP neuron activity is regulated by multiple anatomically and functionally distinct neural circuits. Notably, presystemic regulation during drinking and eating are mediated by non-overlapping circuits that involve the lamina terminalis and hypothalamic arcuate nucleus, respectively. These findings reveal neural mechanisms that support differential regulation of AVP release by diverse behavioral and physiological stimuli.
format	article
author	Angela Kim Joseph C Madara Chen Wu Mark L Andermann Bradford B Lowell
author_facet	Angela Kim Joseph C Madara Chen Wu Mark L Andermann Bradford B Lowell
author_sort	Angela Kim
title	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
title_short	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
title_full	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
title_fullStr	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
title_full_unstemmed	Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
title_sort	neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/359807ebee8d4f77897ed1da66bf84ec
work_keys_str_mv	AT angelakim neuralbasisforregulationofvasopressinsecretionbyanticipateddisturbancesinosmolality AT josephcmadara neuralbasisforregulationofvasopressinsecretionbyanticipateddisturbancesinosmolality AT chenwu neuralbasisforregulationofvasopressinsecretionbyanticipateddisturbancesinosmolality AT marklandermann neuralbasisforregulationofvasopressinsecretionbyanticipateddisturbancesinosmolality AT bradfordblowell neuralbasisforregulationofvasopressinsecretionbyanticipateddisturbancesinosmolality
_version_	1718420836030873600

Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

Ejemplares similares