Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resul...

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Autores principales:	Huiru Zhang, Zhihao Xu, Ying Mao, Yingjie Zhang, Yan Li, Jihong Lao, Lu Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metal-organic frameworks photodynamic therapy antimicrobial nanofibers wound dressing Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/359a1cfd6676436b9a4c32cfe677e80a
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spelling	oai:doaj.org-article:359a1cfd6676436b9a4c32cfe677e80a2021-11-25T18:48:35ZIntegrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application10.3390/polym132239422073-4360https://doaj.org/article/359a1cfd6676436b9a4c32cfe677e80a2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3942https://doaj.org/toc/2073-4360The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best <sup>1</sup>O<sub>2</sub> generation performance, triggering remarkable photodynamic antibacterial effects against both <i>S. aureus</i>, <i>MRSA</i>, and <i>E. coli</i> bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.Huiru ZhangZhihao XuYing MaoYingjie ZhangYan LiJihong LaoLu WangMDPI AGarticlemetal-organic frameworksphotodynamic therapyantimicrobial nanofiberswound dressingOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3942, p 3942 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metal-organic frameworks photodynamic therapy antimicrobial nanofibers wound dressing Organic chemistry QD241-441
spellingShingle	metal-organic frameworks photodynamic therapy antimicrobial nanofibers wound dressing Organic chemistry QD241-441 Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
description	The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best <sup>1</sup>O<sub>2</sub> generation performance, triggering remarkable photodynamic antibacterial effects against both <i>S. aureus</i>, <i>MRSA</i>, and <i>E. coli</i> bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.
format	article
author	Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang
author_facet	Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang
author_sort	Huiru Zhang
title	Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
title_short	Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
title_full	Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
title_fullStr	Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
title_full_unstemmed	Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
title_sort	integrating porphyrinic metal-organic frameworks in nanofibrous carrier for photodynamic antimicrobial application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/359a1cfd6676436b9a4c32cfe677e80a
work_keys_str_mv	AT huiruzhang integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT zhihaoxu integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT yingmao integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT yingjiezhang integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT yanli integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT jihonglao integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication AT luwang integratingporphyrinicmetalorganicframeworksinnanofibrouscarrierforphotodynamicantimicrobialapplication
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Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

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