Significance of food allergy in atopic dermatitis in children

Background. Atopic dermatitis is the most common inflammatory skin disease in childhood, affecting almost 20 % of children. Food allergies affect one of three children with atopic dermatitis, and allergies to peanuts, eggs and milk are the predominant food allergies in the world. The purpose was to...

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Autores principales:	O.P. Volosovets, S.P. Kryvopustov, O.V. Mozyrskaya, N.A. Slusar
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Publishing House Zaslavsky 2021
Materias:	atopic dermatitis, food allergy, children Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/359a259814ae4a04859b2c08331017a4
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spelling	oai:doaj.org-article:359a259814ae4a04859b2c08331017a42021-11-24T09:59:27ZSignificance of food allergy in atopic dermatitis in children2224-05512307-116810.22141/2224-0551.16.7.2021.244573https://doaj.org/article/359a259814ae4a04859b2c08331017a42021-11-01T00:00:00Zhttp://childshealth.zaslavsky.com.ua/article/view/244573https://doaj.org/toc/2224-0551https://doaj.org/toc/2307-1168Background. Atopic dermatitis is the most common inflammatory skin disease in childhood, affecting almost 20 % of children. Food allergies affect one of three children with atopic dermatitis, and allergies to peanuts, eggs and milk are the predominant food allergies in the world. The purpose was to assess the prevalence of food allergies in the group of patients with atopic dermatitis, to determine the association of food allergies with anamnestic and clinical parameters of atopic dermatitis. Materials and methods. Children with atopic dermatitis (n = 116) were included in the study from September 2020 to August 2021 in Kyiv, Ukraine. Food sensitization was established by determining specific immunoglobulin E (sIgE) to food allergens using immunochemiluminescent method on the ImmunoCAP 100 system (Thermo Fisher Scientific Inc., Phadia, Sweden). Results. The average age of children in the main group (59 boys and 57 girls) was 6.8 years. All 116 patients at the time of examination had manifestations of atopic dermatitis in the form of erythematous itchy rash. The number of children with food allergy was 23 (19.8 %). Among food allergens, positive sIgE were found: in 14 patients (12 %) — to milk, in 13 (11.2 %) — to eggs, in 5 (4.3 %) — to fish, and in 4 people (3.4 %) — to hazelnuts. Food sensitization was significantly more common in children with moderate-to-severe atopic dermatitis than in the group of patients with mild atopic dermatitis (χ2 = 7.555, p < 0.05). Children with food sensitization had an earlier onset of atopic dermatitis — the average age of manifestations onset was 8 months, and in the group of children without food allergy, it was 18 months. Children with a parental history of atopic diseases were significantly more likely to have concomitant food allergy (χ2 = 12.831, p < 0.05). Conclusions. Given the significant association between early onset as well as moderate-to-severe atopic dermatitis and food sensitization, it is likely that food sensitization occurs primarily through an inflamed skin barrier in eczematous skin, which could potentially lead to clinical food allergy.O.P. VolosovetsS.P. KryvopustovO.V. MozyrskayaN.A. SlusarPublishing House Zaslavskyarticleatopic dermatitis, food allergy, childrenPediatricsRJ1-570ENRUUKZdorovʹe Rebenka, Vol 16, Iss 7, Pp 455-460 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	atopic dermatitis, food allergy, children Pediatrics RJ1-570
spellingShingle	atopic dermatitis, food allergy, children Pediatrics RJ1-570 O.P. Volosovets S.P. Kryvopustov O.V. Mozyrskaya N.A. Slusar Significance of food allergy in atopic dermatitis in children
description	Background. Atopic dermatitis is the most common inflammatory skin disease in childhood, affecting almost 20 % of children. Food allergies affect one of three children with atopic dermatitis, and allergies to peanuts, eggs and milk are the predominant food allergies in the world. The purpose was to assess the prevalence of food allergies in the group of patients with atopic dermatitis, to determine the association of food allergies with anamnestic and clinical parameters of atopic dermatitis. Materials and methods. Children with atopic dermatitis (n = 116) were included in the study from September 2020 to August 2021 in Kyiv, Ukraine. Food sensitization was established by determining specific immunoglobulin E (sIgE) to food allergens using immunochemiluminescent method on the ImmunoCAP 100 system (Thermo Fisher Scientific Inc., Phadia, Sweden). Results. The average age of children in the main group (59 boys and 57 girls) was 6.8 years. All 116 patients at the time of examination had manifestations of atopic dermatitis in the form of erythematous itchy rash. The number of children with food allergy was 23 (19.8 %). Among food allergens, positive sIgE were found: in 14 patients (12 %) — to milk, in 13 (11.2 %) — to eggs, in 5 (4.3 %) — to fish, and in 4 people (3.4 %) — to hazelnuts. Food sensitization was significantly more common in children with moderate-to-severe atopic dermatitis than in the group of patients with mild atopic dermatitis (χ2 = 7.555, p < 0.05). Children with food sensitization had an earlier onset of atopic dermatitis — the average age of manifestations onset was 8 months, and in the group of children without food allergy, it was 18 months. Children with a parental history of atopic diseases were significantly more likely to have concomitant food allergy (χ2 = 12.831, p < 0.05). Conclusions. Given the significant association between early onset as well as moderate-to-severe atopic dermatitis and food sensitization, it is likely that food sensitization occurs primarily through an inflamed skin barrier in eczematous skin, which could potentially lead to clinical food allergy.
format	article
author	O.P. Volosovets S.P. Kryvopustov O.V. Mozyrskaya N.A. Slusar
author_facet	O.P. Volosovets S.P. Kryvopustov O.V. Mozyrskaya N.A. Slusar
author_sort	O.P. Volosovets
title	Significance of food allergy in atopic dermatitis in children
title_short	Significance of food allergy in atopic dermatitis in children
title_full	Significance of food allergy in atopic dermatitis in children
title_fullStr	Significance of food allergy in atopic dermatitis in children
title_full_unstemmed	Significance of food allergy in atopic dermatitis in children
title_sort	significance of food allergy in atopic dermatitis in children
publisher	Publishing House Zaslavsky
publishDate	2021
url	https://doaj.org/article/359a259814ae4a04859b2c08331017a4
work_keys_str_mv	AT opvolosovets significanceoffoodallergyinatopicdermatitisinchildren AT spkryvopustov significanceoffoodallergyinatopicdermatitisinchildren AT ovmozyrskaya significanceoffoodallergyinatopicdermatitisinchildren AT naslusar significanceoffoodallergyinatopicdermatitisinchildren
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Significance of food allergy in atopic dermatitis in children

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