H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

SETDB1 is a histone methyltransferase that generates H3K9me3 marks in euchromatic regions. Here the authors show that the triple Tudor domain (3TD) of SETDB1 binds histone H3 tails containing K14 acetylation combined with K9 methylation, and that the K9me–K14ac modification defines a novel chromatin...

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Autores principales:	Renata Z. Jurkowska, Su Qin, Goran Kungulovski, Wolfram Tempel, Yanli Liu, Pavel Bashtrykov, Judith Stiefelmaier, Tomasz P. Jurkowski, Srikanth Kudithipudi, Sara Weirich, Raluca Tamas, Hong Wu, Ludmila Dombrovski, Peter Loppnau, Richard Reinhardt, Jinrong Min, Albert Jeltsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/359b9add32a74c369b6c1bb36155be12
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spelling	oai:doaj.org-article:359b9add32a74c369b6c1bb36155be122021-12-02T14:41:08ZH3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB110.1038/s41467-017-02259-92041-1723https://doaj.org/article/359b9add32a74c369b6c1bb36155be122017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02259-9https://doaj.org/toc/2041-1723SETDB1 is a histone methyltransferase that generates H3K9me3 marks in euchromatic regions. Here the authors show that the triple Tudor domain (3TD) of SETDB1 binds histone H3 tails containing K14 acetylation combined with K9 methylation, and that the K9me–K14ac modification defines a novel chromatin state enriched at SETDB1 binding sites.Renata Z. JurkowskaSu QinGoran KungulovskiWolfram TempelYanli LiuPavel BashtrykovJudith StiefelmaierTomasz P. JurkowskiSrikanth KudithipudiSara WeirichRaluca TamasHong WuLudmila DombrovskiPeter LoppnauRichard ReinhardtJinrong MinAlbert JeltschNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renata Z. Jurkowska Su Qin Goran Kungulovski Wolfram Tempel Yanli Liu Pavel Bashtrykov Judith Stiefelmaier Tomasz P. Jurkowski Srikanth Kudithipudi Sara Weirich Raluca Tamas Hong Wu Ludmila Dombrovski Peter Loppnau Richard Reinhardt Jinrong Min Albert Jeltsch H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
description	SETDB1 is a histone methyltransferase that generates H3K9me3 marks in euchromatic regions. Here the authors show that the triple Tudor domain (3TD) of SETDB1 binds histone H3 tails containing K14 acetylation combined with K9 methylation, and that the K9me–K14ac modification defines a novel chromatin state enriched at SETDB1 binding sites.
format	article
author	Renata Z. Jurkowska Su Qin Goran Kungulovski Wolfram Tempel Yanli Liu Pavel Bashtrykov Judith Stiefelmaier Tomasz P. Jurkowski Srikanth Kudithipudi Sara Weirich Raluca Tamas Hong Wu Ludmila Dombrovski Peter Loppnau Richard Reinhardt Jinrong Min Albert Jeltsch
author_facet	Renata Z. Jurkowska Su Qin Goran Kungulovski Wolfram Tempel Yanli Liu Pavel Bashtrykov Judith Stiefelmaier Tomasz P. Jurkowski Srikanth Kudithipudi Sara Weirich Raluca Tamas Hong Wu Ludmila Dombrovski Peter Loppnau Richard Reinhardt Jinrong Min Albert Jeltsch
author_sort	Renata Z. Jurkowska
title	H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
title_short	H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
title_full	H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
title_fullStr	H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
title_full_unstemmed	H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
title_sort	h3k14ac is linked to methylation of h3k9 by the triple tudor domain of setdb1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/359b9add32a74c369b6c1bb36155be12
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H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

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