Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis

Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis

Pimaranes are diterpenoid natural products with poorly characterised biosynthetic pathways. Here pimaranetype diterpenoid synthases are functionally and structurally characterised and shown to exploit distinct modes of intermediate stabilisation.

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Autores principales: Baiying Xing, Jiahui Yu, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang, Ming Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/359db5c499074c4db49f9393292567f1
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spelling oai:doaj.org-article:359db5c499074c4db49f9393292567f12021-12-02T17:37:10ZFunctional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis10.1038/s42004-021-00578-z2399-3669https://doaj.org/article/359db5c499074c4db49f9393292567f12021-09-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00578-zhttps://doaj.org/toc/2399-3669Pimaranes are diterpenoid natural products with poorly characterised biosynthetic pathways. Here pimaranetype diterpenoid synthases are functionally and structurally characterised and shown to exploit distinct modes of intermediate stabilisation.Baiying XingJiahui YuChangbiao ChiXueyang MaQingxia XuAnnan LiYuanjie GeZhengdong WangTan LiuHongli JiaFuling YinJuan GuoLuqi HuangDonghui YangMing MaNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chemistry
QD1-999
spellingShingle Chemistry
QD1-999
Baiying Xing
Jiahui Yu
Changbiao Chi
Xueyang Ma
Qingxia Xu
Annan Li
Yuanjie Ge
Zhengdong Wang
Tan Liu
Hongli Jia
Fuling Yin
Juan Guo
Luqi Huang
Donghui Yang
Ming Ma
Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
description Pimaranes are diterpenoid natural products with poorly characterised biosynthetic pathways. Here pimaranetype diterpenoid synthases are functionally and structurally characterised and shown to exploit distinct modes of intermediate stabilisation.
format article
author Baiying Xing
Jiahui Yu
Changbiao Chi
Xueyang Ma
Qingxia Xu
Annan Li
Yuanjie Ge
Zhengdong Wang
Tan Liu
Hongli Jia
Fuling Yin
Juan Guo
Luqi Huang
Donghui Yang
Ming Ma
author_facet Baiying Xing
Jiahui Yu
Changbiao Chi
Xueyang Ma
Qingxia Xu
Annan Li
Yuanjie Ge
Zhengdong Wang
Tan Liu
Hongli Jia
Fuling Yin
Juan Guo
Luqi Huang
Donghui Yang
Ming Ma
author_sort Baiying Xing
title Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
title_short Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
title_full Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
title_fullStr Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
title_full_unstemmed Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
title_sort functional characterization and structural bases of two class i diterpene synthases in pimarane-type diterpene biosynthesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/359db5c499074c4db49f9393292567f1
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