Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma

Abstract Astrocytoma is the most common glial tumour of the CNS. The most malignant form is grade IV Astrocytoma, also called Glioblastoma. Due to its heterogeneity, aggressiveness and lethal nature scientists are trying to find less invasive methods for early prediction of tumour onset, recurrence,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rūta Urbanavičiūtė, Rūta Zabitaitė, Algimantas Kriščiukaitis, Vytenis-Pranas Deltuva, Daina Skiriutė
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/359f0711f8ad43db828703ec055a4690
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:359f0711f8ad43db828703ec055a4690
record_format	dspace
spelling	oai:doaj.org-article:359f0711f8ad43db828703ec055a46902021-12-02T16:06:08ZSerum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma10.1038/s41598-021-92328-32045-2322https://doaj.org/article/359f0711f8ad43db828703ec055a46902021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92328-3https://doaj.org/toc/2045-2322Abstract Astrocytoma is the most common glial tumour of the CNS. The most malignant form is grade IV Astrocytoma, also called Glioblastoma. Due to its heterogeneity, aggressiveness and lethal nature scientists are trying to find less invasive methods for early prediction of tumour onset, recurrence, response to therapy and patients’ survival. Here, applying decision tree classification algorithm we performed astrocytoma specific protein profile analysis on serum proteins TIMP-1, active and latent form of TGF-β1, IP-10, ANGPT-1, OPN, and YKL-40 using enzyme-linked immunosorbent detection assay (ELISA). Results have demonstrated that astrocytoma specific profile consisted of three proteins—active form of TGF-β1, TIMP-1 and YKL-40 and was able to correctly classify 78.0% (103/132) of sample and 83.3% (60/72) of astrocytoma sample. Calculating decision tree algorithm associated with astrocytoma patient survival, prediction model reached an accuracy of 83.3% (60/72). All together these results indicate that glioma detection and prediction from patient serum using glioma associated proteins and applying mathematical classification tools could be achieved, and applying more comprehensive research further could be implemented in clinic.Rūta UrbanavičiūtėRūta ZabitaitėAlgimantas KriščiukaitisVytenis-Pranas DeltuvaDaina SkiriutėNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rūta Urbanavičiūtė Rūta Zabitaitė Algimantas Kriščiukaitis Vytenis-Pranas Deltuva Daina Skiriutė Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
description	Abstract Astrocytoma is the most common glial tumour of the CNS. The most malignant form is grade IV Astrocytoma, also called Glioblastoma. Due to its heterogeneity, aggressiveness and lethal nature scientists are trying to find less invasive methods for early prediction of tumour onset, recurrence, response to therapy and patients’ survival. Here, applying decision tree classification algorithm we performed astrocytoma specific protein profile analysis on serum proteins TIMP-1, active and latent form of TGF-β1, IP-10, ANGPT-1, OPN, and YKL-40 using enzyme-linked immunosorbent detection assay (ELISA). Results have demonstrated that astrocytoma specific profile consisted of three proteins—active form of TGF-β1, TIMP-1 and YKL-40 and was able to correctly classify 78.0% (103/132) of sample and 83.3% (60/72) of astrocytoma sample. Calculating decision tree algorithm associated with astrocytoma patient survival, prediction model reached an accuracy of 83.3% (60/72). All together these results indicate that glioma detection and prediction from patient serum using glioma associated proteins and applying mathematical classification tools could be achieved, and applying more comprehensive research further could be implemented in clinic.
format	article
author	Rūta Urbanavičiūtė Rūta Zabitaitė Algimantas Kriščiukaitis Vytenis-Pranas Deltuva Daina Skiriutė
author_facet	Rūta Urbanavičiūtė Rūta Zabitaitė Algimantas Kriščiukaitis Vytenis-Pranas Deltuva Daina Skiriutė
author_sort	Rūta Urbanavičiūtė
title	Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
title_short	Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
title_full	Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
title_fullStr	Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
title_full_unstemmed	Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma
title_sort	serum protein triplet tgf-β1, timp-1, and ykl-40 serve as diagnostic and prognostic profile for astrocytoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/359f0711f8ad43db828703ec055a4690
work_keys_str_mv	AT rutaurbanaviciute serumproteintriplettgfb1timp1andykl40serveasdiagnosticandprognosticprofileforastrocytoma AT rutazabitaite serumproteintriplettgfb1timp1andykl40serveasdiagnosticandprognosticprofileforastrocytoma AT algimantaskrisciukaitis serumproteintriplettgfb1timp1andykl40serveasdiagnosticandprognosticprofileforastrocytoma AT vytenispranasdeltuva serumproteintriplettgfb1timp1andykl40serveasdiagnosticandprognosticprofileforastrocytoma AT dainaskiriute serumproteintriplettgfb1timp1andykl40serveasdiagnosticandprognosticprofileforastrocytoma
_version_	1718385079948935168

Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma

Ejemplares similares