Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy

Cold atmospheric plasma has great potential for use in modern medicine. It has been used in the clinical treatment of skin diseases and chronic wounds, and in laboratory settings it has shown effects on selective decrease in tumour-cell viability, reduced tumour mass in animal models and stem-cell p...

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Autores principales:	Dušan Braný, Dana Dvorská, Ján Strnádel, Tatiana Matáková, Erika Halašová, Henrieta Škovierová
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cold atmospheric plasma epigenetic changes non-coding RNA synergistic treatment DNA damage Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/35a040fed7ec4ffaa17b5c40dc688272
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spelling	oai:doaj.org-article:35a040fed7ec4ffaa17b5c40dc6882722021-11-25T17:54:44ZEffect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy10.3390/ijms2222122521422-00671661-6596https://doaj.org/article/35a040fed7ec4ffaa17b5c40dc6882722021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12252https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cold atmospheric plasma has great potential for use in modern medicine. It has been used in the clinical treatment of skin diseases and chronic wounds, and in laboratory settings it has shown effects on selective decrease in tumour-cell viability, reduced tumour mass in animal models and stem-cell proliferation. Many researchers are currently focusing on its application to internal structures and the use of plasma-activated liquids in tolerated and effective human treatment. There has also been analysis of plasma’s beneficial synergy with standard pharmaceuticals to enhance their effect. Cold atmospheric plasma triggers various responses in tumour cells, and this can result in epigenetic changes in both DNA methylation levels and histone modification. The expression and activity of non-coding RNAs with their many important cell regulatory functions can also be altered by cold atmospheric plasma action. Finally, there is ongoing debate whether plasma-produced radicals can directly affect DNA damage in the nucleus or only initiate apoptosis or other forms of cell death. This article therefore summarises accepted knowledge of cold atmospheric plasma’s influence on epigenetic changes, the expression and activity of non-coding RNAs, and DNA damage and its effect in synergistic treatment with routinely used pharmaceuticals.Dušan BranýDana DvorskáJán StrnádelTatiana MatákováErika HalašováHenrieta ŠkovierováMDPI AGarticlecold atmospheric plasmaepigenetic changesnon-coding RNAsynergistic treatmentDNA damageBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12252, p 12252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cold atmospheric plasma epigenetic changes non-coding RNA synergistic treatment DNA damage Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cold atmospheric plasma epigenetic changes non-coding RNA synergistic treatment DNA damage Biology (General) QH301-705.5 Chemistry QD1-999 Dušan Braný Dana Dvorská Ján Strnádel Tatiana Matáková Erika Halašová Henrieta Škovierová Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
description	Cold atmospheric plasma has great potential for use in modern medicine. It has been used in the clinical treatment of skin diseases and chronic wounds, and in laboratory settings it has shown effects on selective decrease in tumour-cell viability, reduced tumour mass in animal models and stem-cell proliferation. Many researchers are currently focusing on its application to internal structures and the use of plasma-activated liquids in tolerated and effective human treatment. There has also been analysis of plasma’s beneficial synergy with standard pharmaceuticals to enhance their effect. Cold atmospheric plasma triggers various responses in tumour cells, and this can result in epigenetic changes in both DNA methylation levels and histone modification. The expression and activity of non-coding RNAs with their many important cell regulatory functions can also be altered by cold atmospheric plasma action. Finally, there is ongoing debate whether plasma-produced radicals can directly affect DNA damage in the nucleus or only initiate apoptosis or other forms of cell death. This article therefore summarises accepted knowledge of cold atmospheric plasma’s influence on epigenetic changes, the expression and activity of non-coding RNAs, and DNA damage and its effect in synergistic treatment with routinely used pharmaceuticals.
format	article
author	Dušan Braný Dana Dvorská Ján Strnádel Tatiana Matáková Erika Halašová Henrieta Škovierová
author_facet	Dušan Braný Dana Dvorská Ján Strnádel Tatiana Matáková Erika Halašová Henrieta Škovierová
author_sort	Dušan Braný
title	Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
title_short	Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
title_full	Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
title_fullStr	Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
title_full_unstemmed	Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy
title_sort	effect of cold atmospheric plasma on epigenetic changes, dna damage, and possibilities for its use in synergistic cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/35a040fed7ec4ffaa17b5c40dc688272
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Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy

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