Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature

Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was refe...

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Autores principales:	Sofia Guidi, Vincenzo Berghella, Giovanni Scambia, Anna Fagotti, Annalisa Vidiri, Stefano Restaino, Giuseppe Vizzielli, Frediano Inzani, Anna Franca Cavaliere
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	granulosa cell tumor pregnancy recurrence ovarian cancer maternal outcome fetal outcome Medicine R
Acceso en línea:	https://doaj.org/article/35a3792d88dc43caa6e57559ac09a483
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spelling	oai:doaj.org-article:35a3792d88dc43caa6e57559ac09a4832021-11-25T17:44:09ZAdult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature10.3390/healthcare91114552227-9032https://doaj.org/article/35a3792d88dc43caa6e57559ac09a4832021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1455https://doaj.org/toc/2227-9032Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was referred to our center at 29 weeks because of a symptomatic abdominal mass, compatible with a possible recurrence of AGCT. At 36 + 3 weeks, she underwent a cesarean delivery for preterm labor and a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, with a 26-month follow-up negative for recurrence. Analyzing our case with the four identified by the literature review, three were recurrent and two were primary AGCT. Only one required surgery for AGCT at 15 weeks, while another underwent chemotherapy in pregnancy. In the other three cases, surgery for AGCT was done at the time of cesarean delivery. There were three cases of preterm delivery. All five pregnancies resulted in the birth of live babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is rare, reported in only five cases. All gave birth to live babies in the third trimester, and maternal outcome at up to 18 months showed no recurrence.Sofia GuidiVincenzo BerghellaGiovanni ScambiaAnna FagottiAnnalisa VidiriStefano RestainoGiuseppe VizzielliFrediano InzaniAnna Franca CavaliereMDPI AGarticlegranulosa cell tumorpregnancyrecurrenceovarian cancermaternal outcomefetal outcomeMedicineRENHealthcare, Vol 9, Iss 1455, p 1455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	granulosa cell tumor pregnancy recurrence ovarian cancer maternal outcome fetal outcome Medicine R
spellingShingle	granulosa cell tumor pregnancy recurrence ovarian cancer maternal outcome fetal outcome Medicine R Sofia Guidi Vincenzo Berghella Giovanni Scambia Anna Fagotti Annalisa Vidiri Stefano Restaino Giuseppe Vizzielli Frediano Inzani Anna Franca Cavaliere Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
description	Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was referred to our center at 29 weeks because of a symptomatic abdominal mass, compatible with a possible recurrence of AGCT. At 36 + 3 weeks, she underwent a cesarean delivery for preterm labor and a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, with a 26-month follow-up negative for recurrence. Analyzing our case with the four identified by the literature review, three were recurrent and two were primary AGCT. Only one required surgery for AGCT at 15 weeks, while another underwent chemotherapy in pregnancy. In the other three cases, surgery for AGCT was done at the time of cesarean delivery. There were three cases of preterm delivery. All five pregnancies resulted in the birth of live babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is rare, reported in only five cases. All gave birth to live babies in the third trimester, and maternal outcome at up to 18 months showed no recurrence.
format	article
author	Sofia Guidi Vincenzo Berghella Giovanni Scambia Anna Fagotti Annalisa Vidiri Stefano Restaino Giuseppe Vizzielli Frediano Inzani Anna Franca Cavaliere
author_facet	Sofia Guidi Vincenzo Berghella Giovanni Scambia Anna Fagotti Annalisa Vidiri Stefano Restaino Giuseppe Vizzielli Frediano Inzani Anna Franca Cavaliere
author_sort	Sofia Guidi
title	Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
title_short	Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
title_full	Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
title_fullStr	Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
title_full_unstemmed	Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
title_sort	adult granulosa cell tumor in pregnancy: a new case and a review of the literature
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/35a3792d88dc43caa6e57559ac09a483
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Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature

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