β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

Abstract β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yue-Ming Ling, Jin-Yu Chen, Libin Guo, Chen-Yi Wang, Wen-Ting Tan, Qing Wen, Shu-Dong Zhang, Guo-Hong Deng, Yao Lin, Hang Fai Kwok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35a3888c4b1b4537837048423ababe71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35a3888c4b1b4537837048423ababe71
record_format	dspace
spelling	oai:doaj.org-article:35a3888c4b1b4537837048423ababe712021-12-02T11:52:30Zβ-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development10.1038/s41598-017-13332-02045-2322https://doaj.org/article/35a3888c4b1b4537837048423ababe712017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13332-0https://doaj.org/toc/2045-2322Abstract β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other β-defensin tested, with the extent and duration of upregulation associated with treatment response. We investigated β-defensin family expression in liver cancer in publicly available datasets and found that among all the β-defensins tested, only β-defensin 1 was significantly downregulated, suggesting β-defensin 1 plays a crucial role in liver cancer development. Further analysis identified E-cadherin as the top positive correlated gene, while hepatocyte growth factor-regulated tyrosine kinase substrate as the top negative correlated gene. Expression of two proteoglycans were also positively correlated with that of β-defensin 1. We have also identified small molecules as potential therapeutic agents to reverse β-defensin 1-associated gene signature. Furthermore, the downregulation of β-defensin 1 and E-cadherin, and upregulation of hepatocyte growth factor-regulated tyrosine kinase substrate, were further confirmed in liver cancer and adjacent normal tissue collected from in-house Chinese liver cancer patients. Together, our results suggest β-defensin 1 plays an important role in protecting HCV progression and liver cancer development.Yue-Ming LingJin-Yu ChenLibin GuoChen-Yi WangWen-Ting TanQing WenShu-Dong ZhangGuo-Hong DengYao LinHang Fai KwokNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yue-Ming Ling Jin-Yu Chen Libin Guo Chen-Yi Wang Wen-Ting Tan Qing Wen Shu-Dong Zhang Guo-Hong Deng Yao Lin Hang Fai Kwok β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
description	Abstract β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other β-defensin tested, with the extent and duration of upregulation associated with treatment response. We investigated β-defensin family expression in liver cancer in publicly available datasets and found that among all the β-defensins tested, only β-defensin 1 was significantly downregulated, suggesting β-defensin 1 plays a crucial role in liver cancer development. Further analysis identified E-cadherin as the top positive correlated gene, while hepatocyte growth factor-regulated tyrosine kinase substrate as the top negative correlated gene. Expression of two proteoglycans were also positively correlated with that of β-defensin 1. We have also identified small molecules as potential therapeutic agents to reverse β-defensin 1-associated gene signature. Furthermore, the downregulation of β-defensin 1 and E-cadherin, and upregulation of hepatocyte growth factor-regulated tyrosine kinase substrate, were further confirmed in liver cancer and adjacent normal tissue collected from in-house Chinese liver cancer patients. Together, our results suggest β-defensin 1 plays an important role in protecting HCV progression and liver cancer development.
format	article
author	Yue-Ming Ling Jin-Yu Chen Libin Guo Chen-Yi Wang Wen-Ting Tan Qing Wen Shu-Dong Zhang Guo-Hong Deng Yao Lin Hang Fai Kwok
author_facet	Yue-Ming Ling Jin-Yu Chen Libin Guo Chen-Yi Wang Wen-Ting Tan Qing Wen Shu-Dong Zhang Guo-Hong Deng Yao Lin Hang Fai Kwok
author_sort	Yue-Ming Ling
title	β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
title_short	β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
title_full	β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
title_fullStr	β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
title_full_unstemmed	β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development
title_sort	β-defensin 1 expression in hcv infected liver/liver cancer: an important role in protecting hcv progression and liver cancer development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/35a3888c4b1b4537837048423ababe71
work_keys_str_mv	AT yuemingling bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT jinyuchen bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT libinguo bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT chenyiwang bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT wentingtan bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT qingwen bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT shudongzhang bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT guohongdeng bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT yaolin bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment AT hangfaikwok bdefensin1expressioninhcvinfectedliverlivercanceranimportantroleinprotectinghcvprogressionandlivercancerdevelopment
_version_	1718395039578587136

β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

Ejemplares similares