Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila

Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila

Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin...

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Autores principales: Seung Kyu Lee, Yutong Xue, Weiping Shen, Yongqing Zhang, Yuyoung Joo, Muzammil Ahmad, Madoka Chinen, Yi Ding, Wai Lim Ku, Supriyo De, Elin Lehrmann, Kevin G. Becker, Elissa P. Lei, Keji Zhao, Sige Zou, Alexei Sharov, Weidong Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/35a40d0fb3f544fea381f448c5f2549b
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spelling oai:doaj.org-article:35a40d0fb3f544fea381f448c5f2549b2021-12-02T14:39:08ZTopoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila10.1038/s41467-018-07101-42041-1723https://doaj.org/article/35a40d0fb3f544fea381f448c5f2549b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07101-4https://doaj.org/toc/2041-1723Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin formation and transcriptional silencing.Seung Kyu LeeYutong XueWeiping ShenYongqing ZhangYuyoung JooMuzammil AhmadMadoka ChinenYi DingWai Lim KuSupriyo DeElin LehrmannKevin G. BeckerElissa P. LeiKeji ZhaoSige ZouAlexei SharovWeidong WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Seung Kyu Lee
Yutong Xue
Weiping Shen
Yongqing Zhang
Yuyoung Joo
Muzammil Ahmad
Madoka Chinen
Yi Ding
Wai Lim Ku
Supriyo De
Elin Lehrmann
Kevin G. Becker
Elissa P. Lei
Keji Zhao
Sige Zou
Alexei Sharov
Weidong Wang
Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
description Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin formation and transcriptional silencing.
format article
author Seung Kyu Lee
Yutong Xue
Weiping Shen
Yongqing Zhang
Yuyoung Joo
Muzammil Ahmad
Madoka Chinen
Yi Ding
Wai Lim Ku
Supriyo De
Elin Lehrmann
Kevin G. Becker
Elissa P. Lei
Keji Zhao
Sige Zou
Alexei Sharov
Weidong Wang
author_facet Seung Kyu Lee
Yutong Xue
Weiping Shen
Yongqing Zhang
Yuyoung Joo
Muzammil Ahmad
Madoka Chinen
Yi Ding
Wai Lim Ku
Supriyo De
Elin Lehrmann
Kevin G. Becker
Elissa P. Lei
Keji Zhao
Sige Zou
Alexei Sharov
Weidong Wang
author_sort Seung Kyu Lee
title Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
title_short Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
title_full Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
title_fullStr Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
title_full_unstemmed Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
title_sort topoisomerase 3β interacts with rnai machinery to promote heterochromatin formation and transcriptional silencing in drosophila
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/35a40d0fb3f544fea381f448c5f2549b
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