Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery

The objective of this study is to develop efficient pH-sensitive hydrogel based on aminated chitosan (AmCs) and gelatin (Gel) biopolymers for oral drug delivery. Herein, AmCs was chemically crosslinked with gelatin (Gel) biopolymer with different ratios, while their structures, thermal profiles and...

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Autores principales:	Ahmed Mohamed Omer, Wagih Abdel-Alim Sadik, Abdel-Ghaffar Maghraby El-Demerdash, Heba Shawky Hassan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Aminated chitosan Gelatin Drug release pH-sensitive hydrogel Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/35a5a0740ce74504bdb31d6c8bad9d0f
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spelling	oai:doaj.org-article:35a5a0740ce74504bdb31d6c8bad9d0f2021-11-18T04:45:55ZFormulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery1319-610310.1016/j.jscs.2021.101384https://doaj.org/article/35a5a0740ce74504bdb31d6c8bad9d0f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319610321001897https://doaj.org/toc/1319-6103The objective of this study is to develop efficient pH-sensitive hydrogel based on aminated chitosan (AmCs) and gelatin (Gel) biopolymers for oral drug delivery. Herein, AmCs was chemically crosslinked with gelatin (Gel) biopolymer with different ratios, while their structures, thermal profiles and morphological properties were investigated by FTIR, TGA and SEM characterization tools, respectively. Moreover, gel-content, crosslinking density and rheological analysis were also performed. The results clarified that the developed AmCs-Gel crosslinked hydrogel displayed variable pH-sensitive swelling profiles. By increasing AmCs ratio, the swelling ratio was boosted at pH 1.2 and declined at pH 7.4. Besides, by increasing gelatin ratio in the hydrogel matrix, the loading efficiency of Oseltamivir phosphate (as a model of drug) was augmented and reached maximum value of 79.0% by AmCs-Gel (2:3) crosslinked hydrogel. The in vitro drug release profiles were investigated for 6 h in simulated gastric fluid [SGF; pH 1.2] and simulated colon fluid [SCF; pH 7.4]. Variable release profiles were realized depending on variation of AmCs and Gel ratios in the crosslinked hydrogel matrix. Finally, the formulated smart crosslinked AmCs-Gel hydrogels demonstrated acceptable biodegradability with no cellular toxicity, suggesting their applicability as pH-sensitive oral drug carriers.Ahmed Mohamed OmerWagih Abdel-Alim SadikAbdel-Ghaffar Maghraby El-DemerdashHeba Shawky HassanElsevierarticleAminated chitosanGelatinDrug releasepH-sensitive hydrogelChemistryQD1-999ENJournal of Saudi Chemical Society, Vol 25, Iss 12, Pp 101384- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aminated chitosan Gelatin Drug release pH-sensitive hydrogel Chemistry QD1-999
spellingShingle	Aminated chitosan Gelatin Drug release pH-sensitive hydrogel Chemistry QD1-999 Ahmed Mohamed Omer Wagih Abdel-Alim Sadik Abdel-Ghaffar Maghraby El-Demerdash Heba Shawky Hassan Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
description	The objective of this study is to develop efficient pH-sensitive hydrogel based on aminated chitosan (AmCs) and gelatin (Gel) biopolymers for oral drug delivery. Herein, AmCs was chemically crosslinked with gelatin (Gel) biopolymer with different ratios, while their structures, thermal profiles and morphological properties were investigated by FTIR, TGA and SEM characterization tools, respectively. Moreover, gel-content, crosslinking density and rheological analysis were also performed. The results clarified that the developed AmCs-Gel crosslinked hydrogel displayed variable pH-sensitive swelling profiles. By increasing AmCs ratio, the swelling ratio was boosted at pH 1.2 and declined at pH 7.4. Besides, by increasing gelatin ratio in the hydrogel matrix, the loading efficiency of Oseltamivir phosphate (as a model of drug) was augmented and reached maximum value of 79.0% by AmCs-Gel (2:3) crosslinked hydrogel. The in vitro drug release profiles were investigated for 6 h in simulated gastric fluid [SGF; pH 1.2] and simulated colon fluid [SCF; pH 7.4]. Variable release profiles were realized depending on variation of AmCs and Gel ratios in the crosslinked hydrogel matrix. Finally, the formulated smart crosslinked AmCs-Gel hydrogels demonstrated acceptable biodegradability with no cellular toxicity, suggesting their applicability as pH-sensitive oral drug carriers.
format	article
author	Ahmed Mohamed Omer Wagih Abdel-Alim Sadik Abdel-Ghaffar Maghraby El-Demerdash Heba Shawky Hassan
author_facet	Ahmed Mohamed Omer Wagih Abdel-Alim Sadik Abdel-Ghaffar Maghraby El-Demerdash Heba Shawky Hassan
author_sort	Ahmed Mohamed Omer
title	Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
title_short	Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
title_full	Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
title_fullStr	Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
title_full_unstemmed	Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
title_sort	formulation of ph-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/35a5a0740ce74504bdb31d6c8bad9d0f
work_keys_str_mv	AT ahmedmohamedomer formulationofphsensitiveaminatedchitosangelatincrosslinkedhydrogelfororaldrugdelivery AT wagihabdelalimsadik formulationofphsensitiveaminatedchitosangelatincrosslinkedhydrogelfororaldrugdelivery AT abdelghaffarmaghrabyeldemerdash formulationofphsensitiveaminatedchitosangelatincrosslinkedhydrogelfororaldrugdelivery AT hebashawkyhassan formulationofphsensitiveaminatedchitosangelatincrosslinkedhydrogelfororaldrugdelivery
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Formulation of pH-sensitive aminated chitosan–gelatin crosslinked hydrogel for oral drug delivery

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