Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema
Athanassios K Giarmoukakis,* Styliani V Blazaki,* Georgios C Bontzos, Argyro D Plaka, Konstantinos N Seliniotakis, Larissa D Ioannidi, Miltiadis K Tsilimbaris Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece*These authors contributed equally to this workCorrespondence...
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Dove Medical Press
2020
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oai:doaj.org-article:35a938fd201c48188e41512953f00f912021-12-02T12:46:50ZEfficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema1178-203Xhttps://doaj.org/article/35a938fd201c48188e41512953f00f912020-11-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-topical-nepafenac-03-in-the-management-of-postoperative-cy-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XAthanassios K Giarmoukakis,* Styliani V Blazaki,* Georgios C Bontzos, Argyro D Plaka, Konstantinos N Seliniotakis, Larissa D Ioannidi, Miltiadis K Tsilimbaris Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece*These authors contributed equally to this workCorrespondence: Miltiadis K TsilimbarisUniversity Hospital of Heraklion, Heraklion 71003, Crete, GreeceTel +302810392351Fax +302810392730Email tsilimb@med.uoc.grPurpose: To assess the effect of twice-daily nepafenac ophthalmic suspension 0.3% on postoperative cystoid-macular-edema (CME).Patients and Methods: In this prospective, clinic-based, non-randomized case-series, 21 patients (21 eyes) were enrolled with either acute or chronic postoperative CME after cataract extraction. Patients were treated with twice-daily nepafenac 0.3% drops, and followed for at least a 4-month period. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT)-derived central retinal thickness (CRT) were measured.Results: From 21 patients, eight presented with acute postoperative CME and 13 with chronic CME. Mean follow-up was 4.82± 1.24 months. No adverse events were reported during the study. Baseline BCVA was 0.49± 0.36 logMAR and improved to 0.36± 0.42 logMAR at the last follow-up visit (P< 0.005). CRT decreased from 450.40± 90.74 μm at baseline to 354.60± 81.49 μm (P< 0.05), following treatment.Conclusion: Our outcomes strongly suggest that administrating nepafenac 0.3% drops on a twice-daily regimen could be a promising alternative for the management of postoperative CME. Additional studies are necessary to further validate our results.Keywords: nepafenac, postoperative macular edema, cataract operation, topical use, treatmentGiarmoukakis AKBlazaki SVBontzos GCPlaka ADSeliniotakis KNIoannidi LDTsilimbaris MKDove Medical Pressarticlenepafenacpostoperative macular edemacataract operationtopical usetreatmentTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 1067-1074 (2020) |
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DOAJ |
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| topic |
nepafenac postoperative macular edema cataract operation topical use treatment Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
nepafenac postoperative macular edema cataract operation topical use treatment Therapeutics. Pharmacology RM1-950 Giarmoukakis AK Blazaki SV Bontzos GC Plaka AD Seliniotakis KN Ioannidi LD Tsilimbaris MK Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| description |
Athanassios K Giarmoukakis,* Styliani V Blazaki,* Georgios C Bontzos, Argyro D Plaka, Konstantinos N Seliniotakis, Larissa D Ioannidi, Miltiadis K Tsilimbaris Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece*These authors contributed equally to this workCorrespondence: Miltiadis K TsilimbarisUniversity Hospital of Heraklion, Heraklion 71003, Crete, GreeceTel +302810392351Fax +302810392730Email tsilimb@med.uoc.grPurpose: To assess the effect of twice-daily nepafenac ophthalmic suspension 0.3% on postoperative cystoid-macular-edema (CME).Patients and Methods: In this prospective, clinic-based, non-randomized case-series, 21 patients (21 eyes) were enrolled with either acute or chronic postoperative CME after cataract extraction. Patients were treated with twice-daily nepafenac 0.3% drops, and followed for at least a 4-month period. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT)-derived central retinal thickness (CRT) were measured.Results: From 21 patients, eight presented with acute postoperative CME and 13 with chronic CME. Mean follow-up was 4.82± 1.24 months. No adverse events were reported during the study. Baseline BCVA was 0.49± 0.36 logMAR and improved to 0.36± 0.42 logMAR at the last follow-up visit (P< 0.005). CRT decreased from 450.40± 90.74 μm at baseline to 354.60± 81.49 μm (P< 0.05), following treatment.Conclusion: Our outcomes strongly suggest that administrating nepafenac 0.3% drops on a twice-daily regimen could be a promising alternative for the management of postoperative CME. Additional studies are necessary to further validate our results.Keywords: nepafenac, postoperative macular edema, cataract operation, topical use, treatment |
| format |
article |
| author |
Giarmoukakis AK Blazaki SV Bontzos GC Plaka AD Seliniotakis KN Ioannidi LD Tsilimbaris MK |
| author_facet |
Giarmoukakis AK Blazaki SV Bontzos GC Plaka AD Seliniotakis KN Ioannidi LD Tsilimbaris MK |
| author_sort |
Giarmoukakis AK |
| title |
Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| title_short |
Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| title_full |
Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| title_fullStr |
Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| title_full_unstemmed |
Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema |
| title_sort |
efficacy of topical nepafenac 0.3% in the management of postoperative cystoid macular edema |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/35a938fd201c48188e41512953f00f91 |
| work_keys_str_mv |
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| _version_ |
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