Proteolysis regulates cardiomyocyte maturation and tissue integration

Proteolysis regulates cardiomyocyte maturation and tissue integration

Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue integrity through the degradation of the TCF3 tra...

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Autores principales: Ryuichi Fukuda, Felix Gunawan, Arica Beisaw, Vanesa Jimenez-Amilburu, Hans-Martin Maischein, Sawa Kostin, Koichi Kawakami, Didier Y. R. Stainier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/35ac95838d1a400d9bec92929d476124
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spelling oai:doaj.org-article:35ac95838d1a400d9bec92929d4761242021-12-02T14:40:59ZProteolysis regulates cardiomyocyte maturation and tissue integration10.1038/ncomms144952041-1723https://doaj.org/article/35ac95838d1a400d9bec92929d4761242017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14495https://doaj.org/toc/2041-1723Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue integrity through the degradation of the TCF3 transcription factor.Ryuichi FukudaFelix GunawanArica BeisawVanesa Jimenez-AmilburuHans-Martin MaischeinSawa KostinKoichi KawakamiDidier Y. R. StainierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ryuichi Fukuda
Felix Gunawan
Arica Beisaw
Vanesa Jimenez-Amilburu
Hans-Martin Maischein
Sawa Kostin
Koichi Kawakami
Didier Y. R. Stainier
Proteolysis regulates cardiomyocyte maturation and tissue integration
description Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue integrity through the degradation of the TCF3 transcription factor.
format article
author Ryuichi Fukuda
Felix Gunawan
Arica Beisaw
Vanesa Jimenez-Amilburu
Hans-Martin Maischein
Sawa Kostin
Koichi Kawakami
Didier Y. R. Stainier
author_facet Ryuichi Fukuda
Felix Gunawan
Arica Beisaw
Vanesa Jimenez-Amilburu
Hans-Martin Maischein
Sawa Kostin
Koichi Kawakami
Didier Y. R. Stainier
author_sort Ryuichi Fukuda
title Proteolysis regulates cardiomyocyte maturation and tissue integration
title_short Proteolysis regulates cardiomyocyte maturation and tissue integration
title_full Proteolysis regulates cardiomyocyte maturation and tissue integration
title_fullStr Proteolysis regulates cardiomyocyte maturation and tissue integration
title_full_unstemmed Proteolysis regulates cardiomyocyte maturation and tissue integration
title_sort proteolysis regulates cardiomyocyte maturation and tissue integration
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/35ac95838d1a400d9bec92929d476124
work_keys_str_mv AT ryuichifukuda proteolysisregulatescardiomyocytematurationandtissueintegration
AT felixgunawan proteolysisregulatescardiomyocytematurationandtissueintegration
AT aricabeisaw proteolysisregulatescardiomyocytematurationandtissueintegration
AT vanesajimenezamilburu proteolysisregulatescardiomyocytematurationandtissueintegration
AT hansmartinmaischein proteolysisregulatescardiomyocytematurationandtissueintegration
AT sawakostin proteolysisregulatescardiomyocytematurationandtissueintegration
AT koichikawakami proteolysisregulatescardiomyocytematurationandtissueintegration
AT didieryrstainier proteolysisregulatescardiomyocytematurationandtissueintegration
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