Armodafinil in the treatment of sleep/wake disorders

Jonathan RL Schwartz1,Thomas Roth2, Chris Drake21INTEGRIS Sleep Disorders Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USAAbstract: Excessive sleepiness (ES) is a major but underestimated pub...

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Autores principales:	Jonathan RL Schwartz, Thomas Roth, Chris Drake
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/35ad7c36407a4362aeda7e6b1be91ec1
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spelling	oai:doaj.org-article:35ad7c36407a4362aeda7e6b1be91ec12021-12-02T07:35:36ZArmodafinil in the treatment of sleep/wake disorders1176-63281178-2021https://doaj.org/article/35ad7c36407a4362aeda7e6b1be91ec12010-07-01T00:00:00Zhttp://www.dovepress.com/armodafinil-in-the-treatment-of-sleepwake-disorders-a4865https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jonathan RL Schwartz1,Thomas Roth2, Chris Drake21INTEGRIS Sleep Disorders Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USAAbstract: Excessive sleepiness (ES) is a major but underestimated public health concern associated with significant impairments in alertness/wakefulness and significant morbidity. The term ES has been used in the sleep medicine literature for years, but due to its nonspecific symptoms (ie tiredness or fatigue), it frequently goes unrecognized or is misdiagnosed in primary care. In some cases ES arises due to poor sleep habits or self-imposed sleep deprivation; however, ES is also a key component of a number of sleep/wake disorders and multiple medical and psychiatric disorders. Identification and treatment of ES is critical to improve the quality of life and well-being of patients and for the safety of the wider community. The inability of patients to recognize the nature, extent, and symptomatic profile of sleep/wake disorders requires vigilance on the part of healthcare professionals. Interventions to address ES and its associated impairments, treatment of the underlying sleep/wake disorder, and follow-up are a priority given the potential for serious consequences if left untreated. Wakefulness-promoting agents are available that treat ES associated with sleep/wake disorders. This review examines current approaches for managing this debilitating and potentially life-threatening condition, focusing on the place of armodafinil as a wakefulness-promoting agent.Keywords: excessive sleepiness, wakefulness, armodafinil, obstructive sleep apnea, narcolepsy, shift-work disorder Jonathan RL SchwartzThomas RothChris DrakeDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 417-427 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jonathan RL Schwartz Thomas Roth Chris Drake Armodafinil in the treatment of sleep/wake disorders
description	Jonathan RL Schwartz1,Thomas Roth2, Chris Drake21INTEGRIS Sleep Disorders Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USAAbstract: Excessive sleepiness (ES) is a major but underestimated public health concern associated with significant impairments in alertness/wakefulness and significant morbidity. The term ES has been used in the sleep medicine literature for years, but due to its nonspecific symptoms (ie tiredness or fatigue), it frequently goes unrecognized or is misdiagnosed in primary care. In some cases ES arises due to poor sleep habits or self-imposed sleep deprivation; however, ES is also a key component of a number of sleep/wake disorders and multiple medical and psychiatric disorders. Identification and treatment of ES is critical to improve the quality of life and well-being of patients and for the safety of the wider community. The inability of patients to recognize the nature, extent, and symptomatic profile of sleep/wake disorders requires vigilance on the part of healthcare professionals. Interventions to address ES and its associated impairments, treatment of the underlying sleep/wake disorder, and follow-up are a priority given the potential for serious consequences if left untreated. Wakefulness-promoting agents are available that treat ES associated with sleep/wake disorders. This review examines current approaches for managing this debilitating and potentially life-threatening condition, focusing on the place of armodafinil as a wakefulness-promoting agent.Keywords: excessive sleepiness, wakefulness, armodafinil, obstructive sleep apnea, narcolepsy, shift-work disorder
format	article
author	Jonathan RL Schwartz Thomas Roth Chris Drake
author_facet	Jonathan RL Schwartz Thomas Roth Chris Drake
author_sort	Jonathan RL Schwartz
title	Armodafinil in the treatment of sleep/wake disorders
title_short	Armodafinil in the treatment of sleep/wake disorders
title_full	Armodafinil in the treatment of sleep/wake disorders
title_fullStr	Armodafinil in the treatment of sleep/wake disorders
title_full_unstemmed	Armodafinil in the treatment of sleep/wake disorders
title_sort	armodafinil in the treatment of sleep/wake disorders
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/35ad7c36407a4362aeda7e6b1be91ec1
work_keys_str_mv	AT jonathanrlschwartz armodafinilinthetreatmentofsleepwakedisorders AT thomasroth armodafinilinthetreatmentofsleepwakedisorders AT chrisdrake armodafinilinthetreatmentofsleepwakedisorders
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Armodafinil in the treatment of sleep/wake disorders

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