Circadian dynamics of the teleost skin immune-microbiome interface

Abstract Background Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised. In aquaculture, light manipulation is com...

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Autores principales:	Amy R. Ellison, David Wilcockson, Jo Cable
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Circadian rhythm Clock gene expression Microbiome Parasite infection Fish Aquaculture Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/35add0e8cfd84c0488b44091bf62f0ee
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spelling	oai:doaj.org-article:35add0e8cfd84c0488b44091bf62f0ee2021-11-21T12:06:40ZCircadian dynamics of the teleost skin immune-microbiome interface10.1186/s40168-021-01160-42049-2618https://doaj.org/article/35add0e8cfd84c0488b44091bf62f0ee2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40168-021-01160-4https://doaj.org/toc/2049-2618Abstract Background Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised. In aquaculture, light manipulation is commonly used to enhance growth and control reproduction but may have unknown negative consequences for animal health. Infectious diseases are a major barrier to sustainable aquaculture and understanding the circadian dynamics of fish immunity and crosstalk with the microbiome is urgently needed. Results Here, using rainbow trout (Oncorhynchus mykiss) as a model, we combine 16S rRNA metabarcoding, metagenomic sequencing and direct mRNA quantification methods to simultaneously characterise the circadian dynamics of skin clock and immune gene expression, and daily changes of skin microbiota. We demonstrate daily rhythms in fish skin immune expression and microbiomes, which are modulated by photoperiod and parasitic lice infection. We identify putative associations of host clock and immune gene profiles with microbial composition. Our results suggest circadian perturbation, that shifts the magnitude and timing of immune and microbiota activity, is detrimental to fish health. Conclusions The substantial circadian dynamics and fish host expression-microbiome relationships we find represent a valuable foundation for investigating the utility of chronotherapies in aquaculture, and more broadly contributes to our understanding of the role of microbiomes in circadian health of vertebrates. Video AbstractAmy R. EllisonDavid WilcocksonJo CableBMCarticleCircadian rhythmClock gene expressionMicrobiomeParasite infectionFishAquacultureMicrobial ecologyQR100-130ENMicrobiome, Vol 9, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Circadian rhythm Clock gene expression Microbiome Parasite infection Fish Aquaculture Microbial ecology QR100-130
spellingShingle	Circadian rhythm Clock gene expression Microbiome Parasite infection Fish Aquaculture Microbial ecology QR100-130 Amy R. Ellison David Wilcockson Jo Cable Circadian dynamics of the teleost skin immune-microbiome interface
description	Abstract Background Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised. In aquaculture, light manipulation is commonly used to enhance growth and control reproduction but may have unknown negative consequences for animal health. Infectious diseases are a major barrier to sustainable aquaculture and understanding the circadian dynamics of fish immunity and crosstalk with the microbiome is urgently needed. Results Here, using rainbow trout (Oncorhynchus mykiss) as a model, we combine 16S rRNA metabarcoding, metagenomic sequencing and direct mRNA quantification methods to simultaneously characterise the circadian dynamics of skin clock and immune gene expression, and daily changes of skin microbiota. We demonstrate daily rhythms in fish skin immune expression and microbiomes, which are modulated by photoperiod and parasitic lice infection. We identify putative associations of host clock and immune gene profiles with microbial composition. Our results suggest circadian perturbation, that shifts the magnitude and timing of immune and microbiota activity, is detrimental to fish health. Conclusions The substantial circadian dynamics and fish host expression-microbiome relationships we find represent a valuable foundation for investigating the utility of chronotherapies in aquaculture, and more broadly contributes to our understanding of the role of microbiomes in circadian health of vertebrates. Video Abstract
format	article
author	Amy R. Ellison David Wilcockson Jo Cable
author_facet	Amy R. Ellison David Wilcockson Jo Cable
author_sort	Amy R. Ellison
title	Circadian dynamics of the teleost skin immune-microbiome interface
title_short	Circadian dynamics of the teleost skin immune-microbiome interface
title_full	Circadian dynamics of the teleost skin immune-microbiome interface
title_fullStr	Circadian dynamics of the teleost skin immune-microbiome interface
title_full_unstemmed	Circadian dynamics of the teleost skin immune-microbiome interface
title_sort	circadian dynamics of the teleost skin immune-microbiome interface
publisher	BMC
publishDate	2021
url	https://doaj.org/article/35add0e8cfd84c0488b44091bf62f0ee
work_keys_str_mv	AT amyrellison circadiandynamicsoftheteleostskinimmunemicrobiomeinterface AT davidwilcockson circadiandynamicsoftheteleostskinimmunemicrobiomeinterface AT jocable circadiandynamicsoftheteleostskinimmunemicrobiomeinterface
_version_	1718419237072011264

Circadian dynamics of the teleost skin immune-microbiome interface

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