Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study

Shichun Du,1,* Hongmei Zhang,1,* Hui Wu,2 Shu Ye,1 Wen Li,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial People&rsqu...

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Autores principales:	Du S, Zhang H, Wu H, Ye S, Li W, Su Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ketosis glucose overweight hyperglycemia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/35b20373e6774a939068e20ebb5e8cd5
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spelling	oai:doaj.org-article:35b20373e6774a939068e20ebb5e8cd52021-12-02T12:58:37ZPrevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study1178-7007https://doaj.org/article/35b20373e6774a939068e20ebb5e8cd52020-08-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-gender-differences-of-metabolic-syndrome-in-young-ketos-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shichun Du,1,* Hongmei Zhang,1,* Hui Wu,2 Shu Ye,1 Wen Li,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou 310014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing SuDepartment of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kong Jiang Road 1665#, Shanghai 200092, People’s Republic of ChinaTel/ Fax +86 2125077538Email suqing@xinhuamed.com.cnPurpose: This study aimed to identify the prevalence and gender differences of metabolic syndrome in young new-onset ketosis-prone type 2 diabetic (KPT2D) individuals.Patients and Methods: A retrospective study was conducted in Shanghai Xin Hua Hospital from 2007 to 2019. A total of 304 patients from 12 to 40 years of age with newly diagnosed diabetes presenting with ketosis were analyzed. The clinical features and laboratory results of KPT2D and type 1 diabetic (T1D) individuals were compared. Prevalence and gender differences of metabolic syndrome in the KPT2D subjects were analyzed.Results: The prevalence of metabolic syndrome (P < 0.0001) was significantly higher in young KPT2D than T1D subjects. The prevalence of high blood pressure (P < 0.0001), central obesity (P < 0.0001), low plasma HDL-C concentration (P = 0.045), and hypertriglyceridemia (P < 0.0001) was elevated in the KPT2D subjects compared with T1D. Male predominance (89%) was presented in the KPT2D subjects. The prevalence of metabolic syndrome (P = 0.0002) was significantly higher in young male than female KPT2D subjects. The presence of central obesity (P < 0.0001) and high blood pressure (P =0.03) was higher in male KPT2D subjects than female. The presence of serum triglyceride concentrations ≥ 2.3mmol/L was significantly higher (P = 0.011) in male KPT2D subjects than female.Conclusion: Significantly higher prevalence of metabolic syndrome in young KPT2D patients compared with T1D patients could be an important reference for diabetic differential diagnosis. KPT2D presented a higher predominance in young males, who had higher prevalence of metabolic syndrome than young females.Keywords: ketosis, glucose, overweight, hyperglycemiaDu SZhang HWu HYe SLi WSu QDove Medical PressarticleketosisglucoseoverweighthyperglycemiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2719-2727 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ketosis glucose overweight hyperglycemia Specialties of internal medicine RC581-951
spellingShingle	ketosis glucose overweight hyperglycemia Specialties of internal medicine RC581-951 Du S Zhang H Wu H Ye S Li W Su Q Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
description	Shichun Du,1,* Hongmei Zhang,1,* Hui Wu,2 Shu Ye,1 Wen Li,1 Qing Su1 1Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of Endocrinology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou 310014, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing SuDepartment of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kong Jiang Road 1665#, Shanghai 200092, People’s Republic of ChinaTel/ Fax +86 2125077538Email suqing@xinhuamed.com.cnPurpose: This study aimed to identify the prevalence and gender differences of metabolic syndrome in young new-onset ketosis-prone type 2 diabetic (KPT2D) individuals.Patients and Methods: A retrospective study was conducted in Shanghai Xin Hua Hospital from 2007 to 2019. A total of 304 patients from 12 to 40 years of age with newly diagnosed diabetes presenting with ketosis were analyzed. The clinical features and laboratory results of KPT2D and type 1 diabetic (T1D) individuals were compared. Prevalence and gender differences of metabolic syndrome in the KPT2D subjects were analyzed.Results: The prevalence of metabolic syndrome (P < 0.0001) was significantly higher in young KPT2D than T1D subjects. The prevalence of high blood pressure (P < 0.0001), central obesity (P < 0.0001), low plasma HDL-C concentration (P = 0.045), and hypertriglyceridemia (P < 0.0001) was elevated in the KPT2D subjects compared with T1D. Male predominance (89%) was presented in the KPT2D subjects. The prevalence of metabolic syndrome (P = 0.0002) was significantly higher in young male than female KPT2D subjects. The presence of central obesity (P < 0.0001) and high blood pressure (P =0.03) was higher in male KPT2D subjects than female. The presence of serum triglyceride concentrations ≥ 2.3mmol/L was significantly higher (P = 0.011) in male KPT2D subjects than female.Conclusion: Significantly higher prevalence of metabolic syndrome in young KPT2D patients compared with T1D patients could be an important reference for diabetic differential diagnosis. KPT2D presented a higher predominance in young males, who had higher prevalence of metabolic syndrome than young females.Keywords: ketosis, glucose, overweight, hyperglycemia
format	article
author	Du S Zhang H Wu H Ye S Li W Su Q
author_facet	Du S Zhang H Wu H Ye S Li W Su Q
author_sort	Du S
title	Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
title_short	Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
title_full	Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
title_fullStr	Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
title_full_unstemmed	Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study
title_sort	prevalence and gender differences of metabolic syndrome in young ketosis-prone type 2 diabetic individuals: a retrospective study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/35b20373e6774a939068e20ebb5e8cd5
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Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study

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