A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.

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Detalles Bibliográficos
Autores principales: Xuanxuan Xing, Daniel P. Kane, Chelsea R. Bulock, Elizabeth A. Moore, Sushma Sharma, Andrei Chabes, Polina V. Shcherbakova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7
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Sumario:Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.