A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuanxuan Xing, Daniel P. Kane, Chelsea R. Bulock, Elizabeth A. Moore, Sushma Sharma, Andrei Chabes, Polina V. Shcherbakova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35b8abf68c3c4cfebd40b90ae653eef7
record_format	dspace
spelling	oai:doaj.org-article:35b8abf68c3c4cfebd40b90ae653eef72021-12-02T15:35:17ZA recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme10.1038/s41467-018-08145-22041-1723https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef72019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08145-2https://doaj.org/toc/2041-1723Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.Xuanxuan XingDaniel P. KaneChelsea R. BulockElizabeth A. MooreSushma SharmaAndrei ChabesPolina V. ShcherbakovaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
description	Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.
format	article
author	Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova
author_facet	Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova
author_sort	Xuanxuan Xing
title	A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_short	A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_full	A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_fullStr	A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_full_unstemmed	A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_sort	recurrent cancer-associated substitution in dna polymerase ε produces a hyperactive enzyme
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7
work_keys_str_mv	AT xuanxuanxing arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT danielpkane arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT chelsearbulock arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT elizabethamoore arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT sushmasharma arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT andreichabes arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT polinavshcherbakova arecurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT xuanxuanxing recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT danielpkane recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT chelsearbulock recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT elizabethamoore recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT sushmasharma recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT andreichabes recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme AT polinavshcherbakova recurrentcancerassociatedsubstitutionindnapolymeraseeproducesahyperactiveenzyme
_version_	1718386588049735680

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Ejemplares similares