A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.
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Nature Portfolio
2019
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oai:doaj.org-article:35b8abf68c3c4cfebd40b90ae653eef72021-12-02T15:35:17ZA recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme10.1038/s41467-018-08145-22041-1723https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef72019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08145-2https://doaj.org/toc/2041-1723Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.Xuanxuan XingDaniel P. KaneChelsea R. BulockElizabeth A. MooreSushma SharmaAndrei ChabesPolina V. ShcherbakovaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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Science Q Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
description |
Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity. |
format |
article |
author |
Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova |
author_facet |
Xuanxuan Xing Daniel P. Kane Chelsea R. Bulock Elizabeth A. Moore Sushma Sharma Andrei Chabes Polina V. Shcherbakova |
author_sort |
Xuanxuan Xing |
title |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
title_short |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
title_full |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
title_fullStr |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
title_full_unstemmed |
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
title_sort |
recurrent cancer-associated substitution in dna polymerase ε produces a hyperactive enzyme |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7 |
work_keys_str_mv |
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