A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.

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Autores principales: Xuanxuan Xing, Daniel P. Kane, Chelsea R. Bulock, Elizabeth A. Moore, Sushma Sharma, Andrei Chabes, Polina V. Shcherbakova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7
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spelling oai:doaj.org-article:35b8abf68c3c4cfebd40b90ae653eef72021-12-02T15:35:17ZA recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme10.1038/s41467-018-08145-22041-1723https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef72019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08145-2https://doaj.org/toc/2041-1723Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.Xuanxuan XingDaniel P. KaneChelsea R. BulockElizabeth A. MooreSushma SharmaAndrei ChabesPolina V. ShcherbakovaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuanxuan Xing
Daniel P. Kane
Chelsea R. Bulock
Elizabeth A. Moore
Sushma Sharma
Andrei Chabes
Polina V. Shcherbakova
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
description Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.
format article
author Xuanxuan Xing
Daniel P. Kane
Chelsea R. Bulock
Elizabeth A. Moore
Sushma Sharma
Andrei Chabes
Polina V. Shcherbakova
author_facet Xuanxuan Xing
Daniel P. Kane
Chelsea R. Bulock
Elizabeth A. Moore
Sushma Sharma
Andrei Chabes
Polina V. Shcherbakova
author_sort Xuanxuan Xing
title A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_short A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_full A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_fullStr A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_full_unstemmed A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
title_sort recurrent cancer-associated substitution in dna polymerase ε produces a hyperactive enzyme
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/35b8abf68c3c4cfebd40b90ae653eef7
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