The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?

Abstract The regenerative capacity of adult human tissues and organs is limited, but recent developments have seen the advent of promising new technologies for regenerative therapy. The human heart is of particular interest for regenerative medicine, as cardiac tissue damage is repaired by the forma...

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Autores principales:	Susanne Sattler, Paul Fairchild, Fiona M. Watt, Nadia Rosenthal, Sian E. Harding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/35bb4dd0174f489ebea55b1cf1e1acf3
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spelling	oai:doaj.org-article:35bb4dd0174f489ebea55b1cf1e1acf32021-12-02T14:22:13ZThe adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?10.1038/s41536-017-0022-32057-3995https://doaj.org/article/35bb4dd0174f489ebea55b1cf1e1acf32017-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0022-3https://doaj.org/toc/2057-3995Abstract The regenerative capacity of adult human tissues and organs is limited, but recent developments have seen the advent of promising new technologies for regenerative therapy. The human heart is of particular interest for regenerative medicine, as cardiac tissue damage is repaired by the formation of rigid scar tissue, which causes inevitable structural changes and progressive functional decline leading to heart failure. Cardiac regenerative medicine aims to prevent scar formation or replace existing scars to halt or reverse adverse remodeling and therapeutic approaches include the use of biomaterials, gene therapies, delivery of growth factors, and (stem) cell therapies. Regenerative therapies, however, face significant obstacles in a hostile microenvironment. While the early immune response to a myocardial infarct is essential to ensure tissue integrity and to avoid fatal cardiac rupture, excessive activation of endogenous repair mechanisms may lead to ongoing inflammation, fibrosis, and sustained autoimmune-mediated tissue damage. Anti-cardiac autoreactivity of the adaptive immune system has been suggested to be involved in structural remodeling, functional decline, and the development of heart failure. It is, therefore, crucial to first understand the endogenous response to cardiac tissue damage and how to restore immune tolerance to cardiac tissue, before additional regenerative therapies can achieve their full potential.Susanne SattlerPaul FairchildFiona M. WattNadia RosenthalSian E. HardingNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Susanne Sattler Paul Fairchild Fiona M. Watt Nadia Rosenthal Sian E. Harding The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
description	Abstract The regenerative capacity of adult human tissues and organs is limited, but recent developments have seen the advent of promising new technologies for regenerative therapy. The human heart is of particular interest for regenerative medicine, as cardiac tissue damage is repaired by the formation of rigid scar tissue, which causes inevitable structural changes and progressive functional decline leading to heart failure. Cardiac regenerative medicine aims to prevent scar formation or replace existing scars to halt or reverse adverse remodeling and therapeutic approaches include the use of biomaterials, gene therapies, delivery of growth factors, and (stem) cell therapies. Regenerative therapies, however, face significant obstacles in a hostile microenvironment. While the early immune response to a myocardial infarct is essential to ensure tissue integrity and to avoid fatal cardiac rupture, excessive activation of endogenous repair mechanisms may lead to ongoing inflammation, fibrosis, and sustained autoimmune-mediated tissue damage. Anti-cardiac autoreactivity of the adaptive immune system has been suggested to be involved in structural remodeling, functional decline, and the development of heart failure. It is, therefore, crucial to first understand the endogenous response to cardiac tissue damage and how to restore immune tolerance to cardiac tissue, before additional regenerative therapies can achieve their full potential.
format	article
author	Susanne Sattler Paul Fairchild Fiona M. Watt Nadia Rosenthal Sian E. Harding
author_facet	Susanne Sattler Paul Fairchild Fiona M. Watt Nadia Rosenthal Sian E. Harding
author_sort	Susanne Sattler
title	The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
title_short	The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
title_full	The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
title_fullStr	The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
title_full_unstemmed	The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
title_sort	adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/35bb4dd0174f489ebea55b1cf1e1acf3
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The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?

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