Chemogenetic ON and OFF switches for RNA virus replication

Therapeutic application of RNA viruses requires tight control over viral activity. Here the authors design a regulatory switch that enables control over activity with clinically approved HIV protease inhibitors.

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Autores principales:	E. Heilmann, J. Kimpel, B. Hofer, A. Rössler, I. Blaas, L. Egerer, T. Nolden, C. Urbiola, H. G. Kräusslich, G. Wollmann, D. von Laer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35bc65b4fdf149b39015ce63f7540b25
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spelling	oai:doaj.org-article:35bc65b4fdf149b39015ce63f7540b252021-12-02T13:34:29ZChemogenetic ON and OFF switches for RNA virus replication10.1038/s41467-021-21630-52041-1723https://doaj.org/article/35bc65b4fdf149b39015ce63f7540b252021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21630-5https://doaj.org/toc/2041-1723Therapeutic application of RNA viruses requires tight control over viral activity. Here the authors design a regulatory switch that enables control over activity with clinically approved HIV protease inhibitors.E. HeilmannJ. KimpelB. HoferA. RösslerI. BlaasL. EgererT. NoldenC. UrbiolaH. G. KräusslichG. WollmannD. von LaerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q E. Heilmann J. Kimpel B. Hofer A. Rössler I. Blaas L. Egerer T. Nolden C. Urbiola H. G. Kräusslich G. Wollmann D. von Laer Chemogenetic ON and OFF switches for RNA virus replication
description	Therapeutic application of RNA viruses requires tight control over viral activity. Here the authors design a regulatory switch that enables control over activity with clinically approved HIV protease inhibitors.
format	article
author	E. Heilmann J. Kimpel B. Hofer A. Rössler I. Blaas L. Egerer T. Nolden C. Urbiola H. G. Kräusslich G. Wollmann D. von Laer
author_facet	E. Heilmann J. Kimpel B. Hofer A. Rössler I. Blaas L. Egerer T. Nolden C. Urbiola H. G. Kräusslich G. Wollmann D. von Laer
author_sort	E. Heilmann
title	Chemogenetic ON and OFF switches for RNA virus replication
title_short	Chemogenetic ON and OFF switches for RNA virus replication
title_full	Chemogenetic ON and OFF switches for RNA virus replication
title_fullStr	Chemogenetic ON and OFF switches for RNA virus replication
title_full_unstemmed	Chemogenetic ON and OFF switches for RNA virus replication
title_sort	chemogenetic on and off switches for rna virus replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35bc65b4fdf149b39015ce63f7540b25
work_keys_str_mv	AT eheilmann chemogeneticonandoffswitchesforrnavirusreplication AT jkimpel chemogeneticonandoffswitchesforrnavirusreplication AT bhofer chemogeneticonandoffswitchesforrnavirusreplication AT arossler chemogeneticonandoffswitchesforrnavirusreplication AT iblaas chemogeneticonandoffswitchesforrnavirusreplication AT legerer chemogeneticonandoffswitchesforrnavirusreplication AT tnolden chemogeneticonandoffswitchesforrnavirusreplication AT curbiola chemogeneticonandoffswitchesforrnavirusreplication AT hgkrausslich chemogeneticonandoffswitchesforrnavirusreplication AT gwollmann chemogeneticonandoffswitchesforrnavirusreplication AT dvonlaer chemogeneticonandoffswitchesforrnavirusreplication
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Chemogenetic ON and OFF switches for RNA virus replication

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