Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications

The gut microbiota is a crucial factor in maintaining homeostasis. The presence of commensal microorganisms leads to the stimulation of the immune system and its maturation. In turn, dysbiosis with an impaired intestinal barrier leads to accelerated contact of microbiota with the host’s immune cells...

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Autores principales:	Marta Potrykus, Sylwia Czaja-Stolc, Marta Stankiewicz, Łukasz Kaska, Sylwia Małgorzewicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microbiome inflammation intestinal epithelial barrier diet prebiotic probiotic Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/35bc93dca77a4666888276bacec66ac7
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spelling	oai:doaj.org-article:35bc93dca77a4666888276bacec66ac72021-11-25T18:34:33ZIntestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications10.3390/nu131138392072-6643https://doaj.org/article/35bc93dca77a4666888276bacec66ac72021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3839https://doaj.org/toc/2072-6643The gut microbiota is a crucial factor in maintaining homeostasis. The presence of commensal microorganisms leads to the stimulation of the immune system and its maturation. In turn, dysbiosis with an impaired intestinal barrier leads to accelerated contact of microbiota with the host’s immune cells. Microbial structural parts, i.e., pathogen-associated molecular patterns (PAMPs), such as flagellin (FLG), peptidoglycan (PGN), lipoteichoic acid (LTA), and lipopolysaccharide (LPS), induce inflammation via activation of pattern recognition receptors. Microbial metabolites can also develop chronic low-grade inflammation, which is the cause of many metabolic diseases. This article aims to systematize information on the influence of microbiota on chronic inflammation and the benefits of microbiota modification through dietary changes, prebiotics, and probiotic intake. Scientific research indicates that the modification of the microbiota in various disease states can reduce inflammation and improve the metabolic profile. However, since there is no pattern for a healthy microbiota, there is no optimal way to modify it. The methods of influencing microbiota should be adapted to the type of dysbiosis. Although there are studies on the microbiota and its effects on inflammation, this subject is still relatively unknown, and more research is needed in this area.Marta PotrykusSylwia Czaja-StolcMarta StankiewiczŁukasz KaskaSylwia MałgorzewiczMDPI AGarticlemicrobiomeinflammationintestinal epithelial barrierdietprebioticprobioticNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3839, p 3839 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome inflammation intestinal epithelial barrier diet prebiotic probiotic Nutrition. Foods and food supply TX341-641
spellingShingle	microbiome inflammation intestinal epithelial barrier diet prebiotic probiotic Nutrition. Foods and food supply TX341-641 Marta Potrykus Sylwia Czaja-Stolc Marta Stankiewicz Łukasz Kaska Sylwia Małgorzewicz Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
description	The gut microbiota is a crucial factor in maintaining homeostasis. The presence of commensal microorganisms leads to the stimulation of the immune system and its maturation. In turn, dysbiosis with an impaired intestinal barrier leads to accelerated contact of microbiota with the host’s immune cells. Microbial structural parts, i.e., pathogen-associated molecular patterns (PAMPs), such as flagellin (FLG), peptidoglycan (PGN), lipoteichoic acid (LTA), and lipopolysaccharide (LPS), induce inflammation via activation of pattern recognition receptors. Microbial metabolites can also develop chronic low-grade inflammation, which is the cause of many metabolic diseases. This article aims to systematize information on the influence of microbiota on chronic inflammation and the benefits of microbiota modification through dietary changes, prebiotics, and probiotic intake. Scientific research indicates that the modification of the microbiota in various disease states can reduce inflammation and improve the metabolic profile. However, since there is no pattern for a healthy microbiota, there is no optimal way to modify it. The methods of influencing microbiota should be adapted to the type of dysbiosis. Although there are studies on the microbiota and its effects on inflammation, this subject is still relatively unknown, and more research is needed in this area.
format	article
author	Marta Potrykus Sylwia Czaja-Stolc Marta Stankiewicz Łukasz Kaska Sylwia Małgorzewicz
author_facet	Marta Potrykus Sylwia Czaja-Stolc Marta Stankiewicz Łukasz Kaska Sylwia Małgorzewicz
author_sort	Marta Potrykus
title	Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
title_short	Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
title_full	Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
title_fullStr	Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
title_full_unstemmed	Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
title_sort	intestinal microbiota as a contributor to chronic inflammation and its potential modifications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/35bc93dca77a4666888276bacec66ac7
work_keys_str_mv	AT martapotrykus intestinalmicrobiotaasacontributortochronicinflammationanditspotentialmodifications AT sylwiaczajastolc intestinalmicrobiotaasacontributortochronicinflammationanditspotentialmodifications AT martastankiewicz intestinalmicrobiotaasacontributortochronicinflammationanditspotentialmodifications AT łukaszkaska intestinalmicrobiotaasacontributortochronicinflammationanditspotentialmodifications AT sylwiamałgorzewicz intestinalmicrobiotaasacontributortochronicinflammationanditspotentialmodifications
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Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications

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